Hyperbranched polyglycerol-based colloid preservation solutions: Toward clinical applications

基于超支化聚甘油的胶体保存溶液：走向临床应用

• 批准号: 478463-2015
• 负责人: Du, Caigan
• 金额: $ 7.31万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=579528
• 关键词: Hyperbranched; polyglycerol; based; colloid; preservation

When an organ, such as the kidney, heart and liver, does not work anymore, a doctor will consider organ transplantation to save the patients life. Organ transplantation is a surgical procedure that consists of removing an organ from one body and implanting it to another; however, damage to the organ occurs in this process due to no blood supply. One technique to limit this damage is to preserve the organ in a cold preservation solution. Several different cold preservations are currently used in the organ transplantation with varying degrees of success, but none of them appears perfect because the damage is still so big, many of transplants do not work after transplantation. Also because of poor prevention of donor organ damage by these solutions, less ideal organs, such as from those donors age greater than 55 years, could not be acceptable for transplantation. This problem not only increases the cost of health care of these transplant patients and affects the survival of the implanted organ afterwards because of transplant damage, but also decreases the use of donor organs worsening the shortage of donor organs. Our objective in this project is to develop a new cold preservation solution based on a novel chemical (called polyglycerol polymer) that will give the best protection of the organ from damage during cold preservation or transplantation. We finished preliminary study for this project, but need financial support from CIHR/NSERC to understand how it works, and further prove the beneficial effects of our novel solution on cold preservation of the organs in all different preclinical models before we are allowed to test it in the hospital.

当肾脏、心脏和肝脏等器官不再工作时，医生会考虑器官移植， 挽救病人的生命。器官移植是一种外科手术，包括从一个身体中取出一个器官， 将其植入另一个器官;然而，由于没有血液供应，在此过程中会发生器官损伤。一种技术来限制 这种损伤是将器官保存在冷保存液中。目前使用几种不同的冷结晶 在器官移植中，有不同程度的成功，但没有一个看起来完美，因为损伤仍然存在。 如此之大，许多移植物在移植后不起作用。也是因为对捐赠器官的损害预防不力， 这些解决方案，不太理想的器官，例如来自年龄大于55岁的供体，对于 移植这个问题不仅增加了这些移植患者的医疗费用， 由于移植后器官的损伤，而且减少了供体器官的使用恶化 捐献器官的短缺我们在这个项目中的目标是开发一种新的冷藏解决方案， 化学品（称为聚甘油聚合物），它将在冷藏过程中最好地保护器官免受损伤，或 移植我们完成了这个项目的初步研究，但需要CIHR/NSERC的财政支持，以了解 它是如何工作的，并进一步证明了我们的新解决方案对所有不同器官的冷保存的有益效果。 临床前的模型，然后才允许我们在医院进行测试。