Hybrid Molecular Imaging in the Diagnosis of Heart Disease

混合分子成像在心脏病诊断中的应用

• 批准号: 478457-2015
• 负责人: Dhanvantari, Savita
• 金额: $ 5.25万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=579523
• 关键词: Hybrid; Molecular; Imaging; Diagnosis; Heart

Brief background of issue: Our group has discovered a molecule, called GHS-R, that may be a marker of heart disease. We would like to develop a technology to detect GHS-R in a non-invasive manner that will help cardiologists in properly diagnosing heart disease in its early stages. The technology is a combination, or hybrid, of two diagnostic imaging methods: positron emission tomography (PET), which will detect GHS-R, and magnetic resonance imaging (MRI), which detects changes in the function of the heart. Combining these two imaging methods will result in a very powerful technology that can measure both molecular and physiological changes in the heart at the same time. Objective of the research proposal: We will develop PET-MRI hybrid imaging to detect changes in GHS-R by PET and heart function by MRI at the same time. This will enable cardiologists to detect very early stages of heart failure. Brief description of research project: We will first test the PET imaging of GHS-R in a mouse model of heart disease. Then we will test the PET-MRI technique in a large animal model of heart disease, because this is the next step to using the technique in humans. Finally, we will work with cardiologist to use the PET-MRI method to detect both GHS-R and heart function in patients with heart disease. How our research will improve the health of Canadians: There is a large segment of the population that has congestive heart failure. These patients represent a high percentage of admitted patients to most acute care hospitals, often requiring several admissions. The ability to detect heart disease at an early point in time, and to gain insight into disease mechanisms that may promote new interventions to limit disease progression hold great promise for the application of the proposed research.

问题背景简介：我们的小组发现了一种名为 GHS-R 的分子，它可能是心脏病的标志物。我们 希望开发一种以非侵入性方式检测 GHS-R 的技术，以帮助心脏病专家正确诊断 早期诊断心脏病。该技术是两种诊断成像方法的组合或混合： 正电子发射断层扫描 (PET)，可检测 GHS-R，以及磁共振成像 (MRI)，可检测 心脏功能的变化。结合这两种成像方法将产生一种非常强大的技术，可以 同时测量心脏的分子和生理变化。 研究计划的目标：我们将开发PET-MRI混合成像，通过PET和心脏检测GHS-R的变化 同时通过 MRI 进行功能。这将使心脏病专家能够检测出心力衰竭的早期阶段。 研究项目简介：我们将首先在心脏病小鼠模型中测试GHS-R的PET成像。然后 我们将在大型心脏病动物模型中测试 PET-MRI 技术，因为这是使用 人类的技术。最后，我们将与心脏病专家合作，使用PET-MRI方法来检测GHS-R和心脏 心脏病患者的功能。 我们的研究将如何改善加拿大人的健康：很大一部分人口患有充血性心脏病 失败。这些患者在大多数急症护理医院的收治患者中所占比例很高，通常需要数次治疗 招生。尽早发现心脏病并深入了解疾病机制的能力 可能会促进新的干预措施来限制疾病进展，这为所提出的研究的应用带来了巨大的希望。