Endovascular navigation of magnetic drug eluting beads for liver cancer therapy: feasibility and optimization

磁性药物洗脱珠血管内导航用于肝癌治疗：可行性和优化

• 批准号: 478474-2015
• 负责人: Martel, Sylvain
• 金额: $ 8.88万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=579539
• 关键词: Endovascular; navigation; magnetic; drug; eluting

HepatoCellular Carcinoma (HCC) (liver cancer) is the fifth most common cancer in the world and third cause of cancer mortality and its incidence is increasing worldwide and intra-arterial therapies are now the preferred therapeutic approach for advanced HCC. Unlike other existing interventional methods, we propose a non-invasive treatment concept which consists in injecting special drug-carrying biodegradable magnetic carriers being navigated directly to the site being treated using a clinical Magnetic Resonance Imaging (MRI) scanner in order to enhance the treatment of liver cancer. We have previously proven its feasibility in a rabbit model. However, the technology must first be adapted to the human scale before considering clinical translation, which is the main goal of this project.

肝细胞癌（HCC）（肝癌）是世界上第五大常见癌症，也是第三大癌症原因 死亡率及其发病率在全球范围内不断增加，动脉内治疗现在是 晚期HCC与其他现有的介入方法不同，我们提出了一种非侵入性治疗概念， 在注射特殊的携带药物的可生物降解的磁性载体时， 临床磁共振成像（MRI）扫描仪，以提高肝癌的治疗。我们先前已经 在兔子模型中证明了它的可行性。然而，在考虑之前，该技术必须首先适应人类规模。 临床翻译，这是这个项目的主要目标。