Behavioral and Neural Substrates of Odor-Guided Navigation in the Human Brain
人脑气味引导导航的行为和神经基础
基本信息
- 批准号:10366995
- 负责人:
- 金额:$ 47.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAirAlzheimer&aposs DiseaseAnimalsBasic ScienceBehaviorBehavioralBiological AssayBirdsBrainCategoriesCellsCharacteristicsCodeCognitiveComplementComputing MethodologiesCuesDataDistalElectroencephalographyEnsureEnvironmentFloorFunctional Magnetic Resonance ImagingGoalsHumanImaging TechniquesImpairmentInsectaLearningLocationMammalsMapsMemoryMethodsModelingMovementNatureNeurobiologyNeuronsNeurosciences ResearchNoseOdorsOlfactory PathwaysOralOral cavityOrganismPathway interactionsPatientsPatternPlayPoaceaePositioning AttributePredictive ValuePredispositionPrefrontal CortexPropertyPsychophysicsReceptor CellResearchRewardsRodentRoleRouteSensorySleepSmell PerceptionSourceSpace PerceptionStimulusSystemTechniquesTestingTravelVisualVisuospatialWorkbasebehavior testcell typedesignentorhinal cortexexperimental studyflexibilityhigh riskhuman imaginghuman subjectinformation processinginsightinterdisciplinary approachneuromechanismnovelpiriform cortexprogramsrelating to nervous systemresponsesensory systemstability testingtwo-dimensionalvirtualvirtual realityvisual informationway finding
项目摘要
ABSTRACT
Sensory systems have evolved to help meet the behavioral needs of organisms to ensure survival. Across the
animal kingdom, two sensory functions are paramount: first, to identify specific objects in the environment and
endow them with salience; and second, to move closer to objects of desire and away from objects that are best
avoided. These properties – identification and localization – are the “what” and “where” questions of sensory
information processing, respectively, and each of the senses provides a unique snapshot of the world that
complements the other senses. In the unique case of olfaction, orthonasal and retronasal olfactory channels
ensure that odor sources can be identified and tracked with fidelity at distal, proximate, and intraoral distances.
This proposed project will focus on the “where” question of information processing in the human olfactory
system. In particular, we aim to understand the capacities, constraints, and mechanisms by which odor cues
orient and steer a navigator in the right direction. In this regard, a singular aspect of odors is their ability to
travel through the air over long distances, such that the olfactory system can gather valuable predictive
information not only about the physical location of an odorous source, but also about the navigator’s position
within a physical landscape. Critically, while elegant neurobiological studies on odor navigation have been
conducted in insects and birds, basic research on this topic in mammals, including humans, is sparse.
Our planned studies are inspired by groundbreaking experiments showing that different types of neurons can
encode and map physical spaces, including “place cells” (representing specific locations in space) and “grid
cells” (representing an internal coordinate system to self-orient in this space). Here we will use functional
magnetic resonance imaging (fMRI), virtual reality (VR) techniques, and computational methods to determine
whether we can infer the presence of “grid-like” fMRI responses when human subjects navigate through an
odor-rich two-dimensional landscape. In Aim 1, subjects will be asked to navigate a VR arena in which the only
informative sensory cues are olfactory, enabling us to test whether subjects can learn the spatial relational
positions among a set of odors, and whether grid-like responses arise during odor navigation. Aim 2 will test
the stability of olfactory grid-like responses by assessing whether contextual changes in the VR arena induce
remapping of olfactory cognitive maps. Aim 3 will test the behavioral limits of human olfactory navigation by
progressively peeling away all remaining visual cues in the arena. Together these studies should bring
fundamental understanding to the capacities and constraints of human olfactory navigation, and should
highlight neural mechanisms underlying the “where” question of human olfaction, and more broadly, how the
olfactory system tracks and locates odor sources in odiferous environments.
摘要
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jay A Gottfried其他文献
Piriform cortex takes sides: temporally-segregated odor representations from ipsilateral and contralateral nostrils within a single sniff
梨状皮层偏向一侧:在一次嗅觉中,同侧和对侧鼻孔的气味表征在时间上分离
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
G. N. Dikecligil;Andrew I. Yang;Nisha Sanghani;Timothy Lucas;H. I. Chen;Kathryn;A. Davis;Jay A Gottfried - 通讯作者:
Jay A Gottfried
Jay A Gottfried的其他文献
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{{ truncateString('Jay A Gottfried', 18)}}的其他基金
Behavioral and Neural Substrates of Odor-Guided Navigation in the Human Brain
人脑气味引导导航的行为和神经基础
- 批准号:
10543149 - 财政年份:2022
- 资助金额:
$ 47.31万 - 项目类别:
Spatiotemporal Mechanisms of Olfactory Processing in the Human Brain
人脑嗅觉处理的时空机制
- 批准号:
10657336 - 财政年份:2020
- 资助金额:
$ 47.31万 - 项目类别:
Spatiotemporal Mechanisms of Olfactory Processing in the Human Brain
人脑嗅觉处理的时空机制
- 批准号:
10376359 - 财政年份:2020
- 资助金额:
$ 47.31万 - 项目类别:
Spatiotemporal Mechanisms of Olfactory Processing in the Human Brain
人脑嗅觉处理的时空机制
- 批准号:
9973570 - 财政年份:2020
- 资助金额:
$ 47.31万 - 项目类别:
Spatiotemporal Mechanisms of Olfactory Processing in the Human Brain
人脑嗅觉处理的时空机制
- 批准号:
9573577 - 财政年份:2017
- 资助金额:
$ 47.31万 - 项目类别:
Spatiotemporal Mechanisms of Olfactory Processing in the Human Brain
人脑嗅觉处理的时空机制
- 批准号:
8846570 - 财政年份:2013
- 资助金额:
$ 47.31万 - 项目类别:
Spatiotemporal Mechanisms of Olfactory Processing in the Human Brain
人脑嗅觉处理的时空机制
- 批准号:
8598418 - 财政年份:2013
- 资助金额:
$ 47.31万 - 项目类别:
Spatiotemporal Mechanisms of Olfactory Processing in the Human Brain
人脑嗅觉处理的时空机制
- 批准号:
8677873 - 财政年份:2013
- 资助金额:
$ 47.31万 - 项目类别:
Spatiotemporal Coding in the Human Olfactory System
人类嗅觉系统的时空编码
- 批准号:
8290213 - 财政年份:2011
- 资助金额:
$ 47.31万 - 项目类别:
Spatiotemporal Coding in the Human Olfactory System
人类嗅觉系统的时空编码
- 批准号:
8203231 - 财政年份:2011
- 资助金额:
$ 47.31万 - 项目类别:
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