权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Identification of new water disinfection byproducts of health importance

鉴定对健康具有重要意义的新型水消毒副产物

基本信息

批准号：
479148-2015
负责人：
Li, XingFang
金额：
$ 12.64万
依托单位：
University of Alberta
依托单位国家：
加拿大
项目类别：
Strategic Projects - Group
财政年份：
2015
资助国家：
加拿大
起止时间：
2015-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=579963
关键词：
Identification new water disinfection byproducts

项目摘要

Emerging drinking water disinfection byproducts (DBPs) are a challenging public health issue because drinking water is a pervasive public exposure. Epidemiological studies have suggested an association of drinking chlorinated water with an increased risk of bladder cancer and possibly other adverse health effects. The regulated DBPs offer no plausible toxicological explanation for increased risks of cancer and adverse health effects that are suggested by epidemiological studies. One possible explanation is that many other unidentified DBPs may play more important roles in the health effects observed, because an estimated majority (~70%) of halogenated DBPs remains unknown. To address the technology challenges and knowledge gaps in monitoring water quality and optimizing disinfection, we propose to develop a new analytical strategy enabling identification of new DBPs, with an emphasis on halogenated peptides. This strategy will be facilitated by new techniques of sample preconcentration and comprehensive mass spectrometry analysis. The outcome of this strategic research project will provide innovative analytical strategy and tools that will broaden DBP research. It will also offer new knowledge enabling the optimization of water treatment to achieve the best quality of drinking water (effective disinfection of pathogens while minimizing risk of DBPs) and to maximize the effectiveness of drinking water guidelines for this pervasive public exposure.

新出现的饮用水消毒副产物（DBPs）是一个具有挑战性的公共卫生问题，因为饮用水是普遍存在的公共暴露。流行病学研究表明，饮用氯化水与膀胱癌风险增加以及可能对健康造成的其他不利影响有关。受调控的dbp对流行病学研究提出的癌症风险增加和不良健康影响没有提供合理的毒理学解释。一种可能的解释是，许多其他未知的dbp可能在观察到的健康影响中发挥更重要的作用，因为估计大多数（~70%）的卤化dbp仍然未知。为了解决监测水质和优化消毒方面的技术挑战和知识空白，我们建议开发一种新的分析策略，以识别新的dbp，重点是卤化肽。样品预浓缩和综合质谱分析的新技术将促进这一战略。这一战略研究项目的成果将提供创新的分析策略和工具，扩大DBP研究。它还将提供新的知识，以优化水处理，以实现最佳的饮用水质量（有效消毒病原体，同时尽量减少dbp的风险），并最大限度地提高针对这种普遍公众接触的饮用水准则的有效性。