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Atherogenic lipoproteins induce macrophage necroptosis and can be targeted for therapeutic and diagnostic interventions in atherosclerosis

Atherogenic lipoproteins induce macrophage necroptosis and can be targeted for therapeutic and diagnostic interventions in atherosclerosis
致动脉粥样硬化脂蛋白可诱导巨噬细胞坏死性凋亡，可作为动脉粥样硬化治疗和诊断干预的目标
批准号：
331757
负责人：
Karunakaran Denuja
金额：
$0.09万
依托单位：
Ottawa Heart Institute Research Corporation (Ontario)
依托单位国家：
加拿大
项目类别：
财政年份：
2015
资助国家：
加拿大
项目状态：
已结题
起止时间：
2015-05-01 至 2016-05-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=331757&lang=en
关键词：
Apoe-/- Animal Models Atherosclerosis Atherosclerotic Therapy Lipoproteins Macrophages Micropet Imaging Necroptosis Radiolabelled Tracers

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中文摘要
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英文摘要
Atherosclerosis is a disease of maladaptive inflammation driven primarily by macrophages, and the atherosclerotic plaque grows when the rate of macrophage accumulation (via recruitment and proliferation) exceeds that of removal (via cell death and egress)
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Activation of RIP1 promotes inflammation in atherosclerosis and obesity: a novel target for cardiometabolic diseases.
Therapeutic silencing of RIP1 targets inflammatory pathways to significantly reduce atherosclerotic lesions and improves plaque stability in Apoe-/- mice
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