Therapeutic silencing of RIP1 targets inflammatory pathways to significantly reduce atherosclerotic lesions and improves plaque stability in Apoe-/- mice
Therapeutic silencing of RIP1 targets inflammatory pathways to significantly reduce atherosclerotic lesions and improves plaque stability in Apoe-/- mice
批准号:
364750
负责人:
Karunakaran Denuja
金额:
$0.07万
依托单位国家:
加拿大
项目类别:
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-01-01
中文摘要
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英文摘要
Atherosclerosis is a maladaptive disease driven primarily by macrophages. As the atherosclerotic plaque progresses, inflammatory and macrophage cell death pathways drive the formation of complex, unstable and rupture-prone lesions with large necrotic core
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会议论文
Activation of RIP1 promotes inflammation in atherosclerosis and obesity: a novel target for cardiometabolic diseases.
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批准号:383203
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项目类别:
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资助金额:$0.07万
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财政年份:2018
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负责人:Karunakaran Denuja
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依托单位:
Atherogenic lipoproteins induce macrophage necroptosis and can be targeted for therapeutic and diagnostic interventions in atherosclerosis
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批准号:331757
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项目类别:
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资助金额:$0.09万
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财政年份:2015
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负责人:Karunakaran Denuja
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依托单位:
国内基金
海外基金
炎性反应中巨噬细胞激活诱导死亡(activation-induced cell death,AICD)的机理研究
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批准号:30330260
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项目类别:重点项目
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资助金额:105.0万元
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批准年份:2003
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负责人:顾军
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依托单位: