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Therapeutic silencing of RIP1 targets inflammatory pathways to significantly reduce atherosclerotic lesions and improves plaque stability in Apoe-/- mice

Therapeutic silencing of RIP1 targets inflammatory pathways to significantly reduce atherosclerotic lesions and improves plaque stability in Apoe-/- mice
RIP1 的治疗性沉默以炎症途径为目标,可显着减少 Apoe-/- 小鼠的动脉粥样硬化病变并改善斑块稳定性
批准号:
364750
负责人:
Karunakaran Denuja
金额:
$0.07万
依托单位国家:
加拿大
项目类别:
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-01-01

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中文摘要
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英文摘要
Atherosclerosis is a maladaptive disease driven primarily by macrophages. As the atherosclerotic plaque progresses, inflammatory and macrophage cell death pathways drive the formation of complex, unstable and rupture-prone lesions with large necrotic core
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会议论文
Activation of RIP1 promotes inflammation in atherosclerosis and obesity: a novel target for cardiometabolic diseases.
Atherogenic lipoproteins induce macrophage necroptosis and can be targeted for therapeutic and diagnostic interventions in atherosclerosis
国内基金
海外基金
炎性反应中巨噬细胞激活诱导死亡(activation-induced cell death,AICD)的机理研究
  • 批准号:
    30330260
  • 项目类别:
    重点项目
  • 资助金额:
    105.0万元
  • 批准年份:
    2003
  • 负责人:
    顾军
  • 依托单位: