Genetically engineering U937 cells to deliver anti-tumor necrosis factor alpha (anti-TNFa) to the central nervous system (CNS) to alleviate inflammation in Parkinson's disease

基因工程 U937 细胞将抗肿瘤坏死因子 α（抗 TNFa）传递至中枢神经系统 (CNS)，以减轻帕金森病的炎症

• 批准号: 351922
• 负责人: Qudrat Anam
• 金额: $ 7.65万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-10-01 至 2018-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=351922&lang=en
• 关键词: Cytokines; Inflammation; Lentiviral Infection; Microglia; Monocytes (I.E.; U937)

Parkinson's disease (PD) is a late-onset neurodegenerative disorder, characterized by motor and cognitive impairments, critically debilitating the elderly (i.e., > 65 years) Canadian population. Widespread neuronal loss impairs function of the central ner

帕金森病（PD）是一种迟发性神经退行性疾病，以运动和认知障碍为特征，严重损害加拿大老年人（即65岁以上）。广泛的神经元丧失损害中枢神经的功能