Capacity of human muscle satellite stem cells isolated from Obese Diet Sensitive versus Obese Diet Resistant subjects for brown adipogenic transformation in response to antagomir silencing of miRNA-133

从肥胖饮食敏感与肥胖饮食抗性受试者中分离的人类肌肉卫星干细胞响应 miRNA-133 antagomir 沉默而进行棕色脂肪形成转化的能力

• 批准号: 339378
• 负责人: McMurray Fiona
• 金额: $ 9.29万
• 依托单位: University of Ottawa Heart Institute
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-11-01 至 2018-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=339378&lang=en
• 关键词: Adipose Tissue; Antagomir; Bioenergetics; Brown Adipose Tissue; Diabetes; Diet Sensitivity; Metabolism; Muscle; Obesity; Stem Cells

Obesity has become one of the most serious health problems in Canada. Treatment options are limited to behavioural therapy including diet and exercise, a very limited repertoire of poorly effective medications, and surgery. Surgery is effective but is exp

肥胖已成为加拿大最严重的健康问题之一。治疗选择仅限于行为治疗，包括饮食和锻炼，非常有限的低效药物和手术。手术是有效的，但太昂贵了