Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
基本信息
- 批准号:RGPIN-2014-06278
- 负责人:
- 金额:$ 1.46万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2015
- 资助国家:加拿大
- 起止时间:2015-01-01 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Canadian Blood Services (CBS) spends $1B to provide Canadians with a safe supply of blood. As pressures mount to constrain costs, there is a need to improve the efficiency of the blood supply chain.
Blood products are perishable and thus subject to wastage. Managing blood inventory is difficult because ordering decisions must consider the age of stock. Historically, the literature on blood supply chain management has focused on Red Blood Cell (RBC) inventory policies for a single supplier or consumer. However, because of proposed changes to the storage limits of red blood cells (RBC), end-to-end supply chain modelling has recently become a topic of interest for researchers and blood agencies around the globe.
Currently, we are working on a modelling framework to represent ten regional blood distribution networks in Canada. Our ongoing work has produced an approach that represents a significant step forward in terms of scope, detail, and re-usability of supply chain models for regional blood distribution networks. We propose to extend our regional modelling framework to address four important issues in blood supply chain management.
1) The impact of a shorter shelf-life for RBC: Recent studies have raised questions about the safety of RBC after storage. However, reducing shelf life would likely create shortages or substantially increase product wastage. Thus, there is a need to determine the impact of a reduced shelf life for RBC. We will use our regional modelling framework to evaluate a shorter shelf life for RBC in each of the ten CBS blood distribution networks. By evaluating the impact of a shorter shelf life across a class of problems we can generalize results and frame the ongoing debate regarding the costs and benefits of transfusing newer blood.
2) Non-FIFO issuing policies: It has been well established that optimal policies for perishable blood products follow first-in-first-out (FIFO) rules. However, the spectre of a shorter shelf life for RBC has renewed interest in non-FIFO policies. Recently, several papers describing non-FIFO issuing have appeared. A distinguishing feature of this literature is the unitary scope of analysis, which focuses only on hospital issuing policies; the broader context of how non-FIFO issuing policies would work in a network has not yet been investigated. We will extend our framework to evaluate non-FIFO issuing policies from a network standpoint.
3) Age equitable distribution policies: The age of RBC issued to hospitals in Canada is not uniform. Larger facilities, which tend to turn stock more frequently, are supplied with older stock, while smaller facilities get newer stock. This practice maximizes product availability at distant sites and lowers delivery costs. However, it has been suggested that it leads to more frequent transfusion requirements and poorer outcomes for some patients. There is a need to develop issuing policies that promote equitable age distribution of blood products across an entire network to ensure all Canadians have equitable access to safe and effective blood products.
4) Dynamic inventory re-balancing: While inventory is managed on a regional level in Canada, blood is a national resource and materials flow, either on a planned or ad hoc basis, between regions. Approximately 20% of all RBC collected by CBS are transferred between sites. No study has established a scientific basis for control policies currently used to re-balance blood inventory in Canada. We will employ simulation based optimization (SBO) methods to evaluate policies for inventory re-balancing between CBS distribution sites. This project will help to reduce operational costs at CBS while promoting more reliable access to needed blood products across the country.
加拿大血液服务(CBS)花费10亿美元为加拿大人提供安全的血液供应。随着控制成本的压力越来越大,有必要提高血液供应链的效率。
血液产品容易腐烂,因此容易被浪费。管理血液库存是困难的,因为订购决定必须考虑库存的年龄。从历史上看,有关血液供应链管理的文献主要关注针对单一供应商或消费者的红细胞(RBC)库存政策。然而,由于对红细胞(RBC)储存极限的拟议改变,端到端供应链建模最近已成为全球研究人员和血液机构感兴趣的话题。
目前,我们正在研究一个模型框架,以代表加拿大的十个区域血液分配网络。我们正在进行的工作已经产生了一种方法,在区域血液分配网络的供应链模型的范围、细节和可重用性方面向前迈出了重要的一步。我们建议扩展我们的区域建模框架,以解决血液供应链管理中的四个重要问题。
1)红血球保质期缩短的影响:最近的研究对红血球储存后的安全性提出了质疑。然而,缩短保质期可能会造成短缺或大幅增加产品浪费。因此,有必要确定红细胞保质期缩短的影响。我们将使用我们的区域建模框架来评估十个CBS血液分配网络中每一个RBC的较短保质期。通过评估较短的保质期对一类问题的影响,我们可以概括结果,并框定正在进行的关于输注更新血液的成本和好处的辩论。
2)非先进先出(Non-FIFO)政策:对于易腐烂的血液产品,最优政策遵循先进先出(FIFO)规则,这是公认的。然而,RBC保质期缩短的幽灵重新引起了人们对非FIFO政策的兴趣。最近,出现了几篇描述非FIFO发行的论文。这篇文献的一个显著特点是分析范围单一,只关注医院发放政策;还没有调查非先进先出发放政策在网络中如何发挥作用的更广泛的背景。我们将扩展我们的框架,从网络的角度来评估非FIFO发行政策。
3)年龄公平分配政策:加拿大医院发放的红细胞年龄不统一。较大的设施往往更频繁地周转库存,供应的是较旧的库存,而较小的设施则提供较新的库存。这种做法最大限度地提高了远程站点的产品可用性,并降低了交付成本。然而,有人认为,这会导致一些患者更频繁地需要输血,结果更差。需要制定发证政策,促进血液产品在整个网络中的公平年龄分布,以确保所有加拿大人平等地获得安全和有效的血液产品。
4)动态库存再平衡:在加拿大,虽然库存是在区域一级管理的,但血液是国家资源和区域之间的物质流动,无论是在计划的基础上还是临时的基础上。CBS收集的所有RBC中约有20%在站点之间转移。目前还没有研究为加拿大目前用于重新平衡血液库存的控制政策建立科学基础。我们将使用基于模拟的优化(SBO)方法来评估CBS配送站点之间的库存再平衡策略。该项目将有助于降低CBS的运营成本,同时促进在全国范围内更可靠地获得所需的血液产品。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Blake, John其他文献
Attachment, Hope, and Participation: Testing an Expanded Model of Snyder's Hope Theory for Prediction of Participation for Individuals With Spinal Cord Injury
- DOI:
10.1037/rep0000204 - 发表时间:
2018-05-01 - 期刊:
- 影响因子:2.7
- 作者:
Blake, John;Yaghmaian, Rana;Chan, Fong - 通讯作者:
Chan, Fong
Speech Processing for Language Learning: A Practical Approach to Computer-Assisted Pronunciation Teaching
- DOI:
10.3390/electronics10030235 - 发表时间:
2021-02-01 - 期刊:
- 影响因子:2.9
- 作者:
Bogach, Natalia;Boitsova, Elena;Blake, John - 通讯作者:
Blake, John
Transitioning to Full Field Digital Mammography in Nova Scotia: Using Interrupted Time Series Methods to Study the Impact of Technology Change on Mammography Volumes
- DOI:
10.1016/j.jmir.2020.03.001 - 发表时间:
2020-06-01 - 期刊:
- 影响因子:1.8
- 作者:
Brydon, Megan;Kephart, George;Blake, John - 通讯作者:
Blake, John
Hibernation in Black Bears: Independence of Metabolic Suppression from Body Temperature
- DOI:
10.1126/science.1199435 - 发表时间:
2011-02-18 - 期刊:
- 影响因子:56.9
- 作者:
Toien, Oivind;Blake, John;Barnes, Brian M. - 通讯作者:
Barnes, Brian M.
Thermoregulation and energetics in hibernating black bears: metabolic rate and the mystery of multi-day body temperature cycles
- DOI:
10.1007/s00360-015-0891-y - 发表时间:
2015-05-01 - 期刊:
- 影响因子:2
- 作者:
Toien, Oivind;Blake, John;Barnes, Brian M. - 通讯作者:
Barnes, Brian M.
Blake, John的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Blake, John', 18)}}的其他基金
Improving Canada's blood network using operational research
利用运筹学改善加拿大的血液网络
- 批准号:
RGPIN-2022-03232 - 财政年份:2022
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
- 批准号:
RGPIN-2014-06278 - 财政年份:2021
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
- 批准号:
RGPIN-2014-06278 - 财政年份:2020
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
- 批准号:
RGPIN-2014-06278 - 财政年份:2017
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
- 批准号:
RGPIN-2014-06278 - 财政年份:2016
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
- 批准号:
RGPIN-2014-06278 - 财政年份:2014
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Robust reusable reliable models for health care optimization
用于医疗保健优化的稳健、可重复使用的可靠模型
- 批准号:
203530-2007 - 财政年份:2011
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Robust reusable reliable models for health care optimization
用于医疗保健优化的稳健、可重复使用的可靠模型
- 批准号:
203530-2007 - 财政年份:2010
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Robust reusable reliable models for health care optimization
用于医疗保健优化的稳健、可重复使用的可靠模型
- 批准号:
203530-2007 - 财政年份:2009
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Robust reusable reliable models for health care optimization
用于医疗保健优化的稳健、可重复使用的可靠模型
- 批准号:
203530-2007 - 财政年份:2008
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
相似海外基金
Improving Canada's blood network using operational research
利用运筹学改善加拿大的血液网络
- 批准号:
RGPIN-2022-03232 - 财政年份:2022
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
- 批准号:
RGPIN-2014-06278 - 财政年份:2021
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
- 批准号:
RGPIN-2014-06278 - 财政年份:2020
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Research on gaze control using Mixed Reality and operational performance improvement of welfare vehicles for the elderly
混合现实视线控制及老年福利车运行性能提升研究
- 批准号:
20K04353 - 财政年份:2020
- 资助金额:
$ 1.46万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Uncovering the mechanisms of effective facilitated operational research using psychology
利用心理学揭示有效促进运筹学的机制
- 批准号:
2289760 - 财政年份:2019
- 资助金额:
$ 1.46万 - 项目类别:
Studentship
Low-complexity decoupling of multi-frequency arrays for magnetic resonance imaging and spectroscopy using operational amplifiers
使用运算放大器对磁共振成像和光谱学的多频阵列进行低复杂度解耦
- 批准号:
9809911 - 财政年份:2019
- 资助金额:
$ 1.46万 - 项目类别:
Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
- 批准号:
RGPIN-2014-06278 - 财政年份:2017
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
- 批准号:
RGPIN-2014-06278 - 财政年份:2016
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Using operational research methods to improve decision making in Canada's blood supply chain
利用运筹学方法改善加拿大血液供应链的决策
- 批准号:
RGPIN-2014-06278 - 财政年份:2014
- 资助金额:
$ 1.46万 - 项目类别:
Discovery Grants Program - Individual
Collaborative Research: VOCALS--Climate Simulation and Operational Forecasting Using a Regional Earth System Modeling Framework
合作研究:VOCALS——使用区域地球系统建模框架进行气候模拟和业务预测
- 批准号:
0748012 - 财政年份:2008
- 资助金额:
$ 1.46万 - 项目类别:
Continuing Grant