Cellular and molecular mechanisms of inflammatory T cell regulation.

炎症 T 细胞调节的细胞和分子机制。

• 批准号: RGPIN-2015-03665
• 负责人: Rangachari, Manu
• 金额: $ 2.33万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589303
• 关键词: Cellular; molecular; mechanisms; inflammatory; cell

T cells of the immune system proliferate rapidly in response to bacteria, viruses and tumors. They co-ordinate the body’s response to pathogens and cancer by either killing infected cells directly, or by attracting other accessory immune cells to promote inflammation. As T cells can multiply at a dramatic rate in response to infection, and as they produce many antimicrobial and antiviral molecules that can be toxic to the body in large amounts, it is crucial that T cell responses be tightly controlled. T cells thus express negative signaling receptors on their surface. Triggering of negative surface receptors leads to the activation of protein signaling pathways within the T cell, causing them to either die or to reduce their pro-inflammatory functions.

免疫系统的T细胞迅速增殖，以应对细菌、病毒和肿瘤。它们通过直接杀死受感染的细胞或通过吸引其他附属免疫细胞促进炎症来协调身体对病原体和癌症的反应。由于T细胞可以在感染后以惊人的速度繁殖，并且它们产生许多可能对身体有害的抗微生物和抗病毒分子，因此严格控制T细胞的反应是至关重要的。因此，T细胞在其表面表达负信号受体。负表面受体的触发会激活T细胞内的蛋白质信号通路，导致它们要么死亡，要么降低其促炎功能。