Role of ion channels from the Cys-loop family in autonomic function

Cys环家族离子通道在自主功能中的作用

• 批准号: RGPIN-2015-03958
• 负责人: Campanucci, Veronica
• 金额: $ 1.75万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589497
• 关键词: Role; ion; channels; Cys; loop

Serotonergic type 3 receptors (5HT3Rs) are members of the Cys-loop family of ligand-gated ion channels, which they share with nicotinic ACh, GABAA and glycine receptors. All members of this family are widely expressed in the nervous system where they mostly participate in fast synaptic transmission. In the periphery, activation of nAChRs drive fast synaptic transmission at sympathetic and parasympathetic ganglia; while activation of 5HT3Rs on vagal sensory nerve endings affect respiration, circulation, emesis and nociception. Although 5HT3Rs are functionally expressed in autonomic neurons their function has not been yet fully determined. In the current grant proposal we will concentrate in the following research aims:

5 -羟色胺能3型受体（5HT3Rs）是Cys-loop家族配体门控离子通道的成员，它们与烟碱ACh、GABAA和甘氨酸受体共享。该家族的所有成员在神经系统中广泛表达，主要参与快速突触传递。在外周，nachr的激活驱动交感神经节和副交感神经节的快速突触传递；而5HT3Rs在迷走感觉神经末梢的激活影响呼吸、循环、呕吐和伤害感受。尽管5HT3Rs在自主神经元中有功能性表达，但其功能尚未完全确定。在目前的拨款申请中，我们将集中于以下研究目标：