Role of ion channels from the Cys-loop family in autonomic function
Role of ion channels from the Cys-loop family in autonomic function
批准号:
RGPIN-2015-03958
负责人:
Campanucci, Veronica
金额:
$1.75万
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-01-01 至 2016-12-31
中文摘要
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英文摘要
Serotonergic type 3 receptors (5HT3Rs) are members of the Cys-loop family of ligand-gated ion channels, which they share with nicotinic ACh, GABAA and glycine receptors. All members of this family are widely expressed in the nervous system where they mostly participate in fast synaptic transmission. In the periphery, activation of nAChRs drive fast synaptic transmission at sympathetic and parasympathetic ganglia; while activation of 5HT3Rs on vagal sensory nerve endings affect respiration, circulation, emesis and nociception. Although 5HT3Rs are functionally expressed in autonomic neurons their function has not been yet fully determined. In the current grant proposal we will concentrate in the following research aims:
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Chloride homeostasis and DRG neuron excitability
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项目类别:Discovery Grants Program - Individual
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Role of ion channels from the Cys-loop family in autonomic function
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批准号:RGPIN-2015-03958
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.75万
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财政年份:2019
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负责人:Campanucci, Veronica
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依托单位:
Role of ion channels from the Cys-loop family in autonomic function
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批准号:RGPIN-2015-03958
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.75万
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财政年份:2018
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负责人:Campanucci, Veronica
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依托单位:
Role of ion channels from the Cys-loop family in autonomic function
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批准号:RGPIN-2015-03958
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.75万
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负责人:Campanucci, Veronica
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依托单位:
Role of ion channels from the Cys-loop family in autonomic function
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批准号:RGPIN-2015-03958
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.75万
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依托单位:
Structure-function relationship of ion channels from the Cys-loop family
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.77万
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依托单位:
Structure-function relationship of ion channels from the Cys-loop family
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批准号:371702-2010
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资助金额:$2.77万
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依托单位:
Structure-function relationship of ion channels from the Cys-loop family
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批准号:371702-2010
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项目类别:Discovery Grants Program - Individual
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Structure-function relationship of ion channels from the Cys-loop family
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Structure-function relationship of ion channels from the Cys-loop family
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资助金额:$0.75万
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依托单位:
国内基金
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