Molecular interactions and the chemotropic effects of Netrin-1 via receptor binding: a key to oligodendrocyte precursor cell migration and myelination in multiple sclerosis

Netrin-1 通过受体结合的分子相互作用和趋化作用：多发性硬化症中少突胶质细胞前体细胞迁移和髓鞘形成的关键

• 批准号: 349935
• 负责人: Wiens Julia K
• 金额: $ 1.27万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-12-01 至 2016-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=349935&lang=en
• 关键词: Atomic Resolution Model; Axon Guidance; Crystallography; Multiple Sclerosis; Myelin Sheaths; Netrin-1; Oligodendrocyte Precursor Cells (Opc); Opc Differentiation And Migration; Receptor-Ligand Molecular Interactions; Signalling Cascade

Multiple sclerosis (MS) is an autoimmune neurodegenerative disorder of the Central Nervous System (CNS) where myelin repair mechanisms are inhibited and demyelination occurs resulting in axonal loss. Oligodendrocyte precursor cells (OPCs) change and matur

多发性硬化症(MS)是一种中枢神经系统(CNS)自身免疫性神经退行性疾病，髓鞘修复机制受到抑制，脱髓鞘导致轴突丢失。少突胶质前体细胞的变化和成熟