Regulation of KATP and Cl channel activity by AMPK, ATP and adenosine receptors: impact on membrane excitability during muscle activity and fatigue

AMPK、ATP 和腺苷受体对 KATP 和 Cl 通道活性的调节：对肌肉活动和疲劳期间膜兴奋性的影响

• 批准号: RGPIN-2015-04437
• 负责人: Renaud, JeanMarc
• 金额: $ 2.91万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589800
• 关键词: Regulation; KATP; Cl; channel; activity

Noteworthy are complex changes in ion channel activity in the cell membrane during skeletal muscle activity. The first change, occurring during Phase 1, starts at the onset of muscle activity and is characterized by a 70% decreases in ClC-1 Cl

值得注意的是骨骼肌活动期间细胞膜中离子通道活性的复杂变化。第一个变化发生在第 1 阶段，从肌肉活动开始时开始，其特征是 ClC-1 Cl 降低 70%