Role of the cytoskeleton in granulocyte activation and inflammation.

细胞骨架是一种动态结构，被几种抗癌药物靶向以阻止细胞增殖。在刺激时，在各种细胞中发生细胞骨架的显著重组。目前的研究计划集中在免疫系统的一种细胞类型，即在炎症中起关键作用的中性粒细胞。特别是，在激活的中性粒细胞发挥不同功能以对抗外来病原体的过程中，细胞骨架发生重组。拟议的研究计划的主要目标是阐明中性粒细胞的一般细胞生物学和生理学中的不同细胞骨架结构的作用。这一点很重要，因为这些细胞必须受到严格控制，以保持良好的健康。如果发生失调，这可能导致几种炎症性疾病。因此，我们的工作旨在了解细胞骨架在中性粒细胞和炎症生理学中的作用和参与，对所有加拿大人都很重要，特别是那些患有炎症性疾病的人以及暴露于促炎剂（粉尘，化学品，纳米颗粒等）的工人。研究人员、临床医生、风险管理人员等，

The cell cytoskeleton is a dynamic structure that is targeted by several anti-cancer drugs to arrest cell proliferation. Upon stimulation, a significant re-organization of the cytoskeleton occurs in a variety of cells. The present research program focuses on one cell type of the immune system, the neutrophil that is a key player in inflammation. Especially, re-organization of the cytoskeleton occurs in activated neutrophils during different functions exerted by these cells to fight foreign pathogens. The main objective of the proposed research program is to elucidate the role of the different cytoskeletal structures in the general cell biology and physiology of the neutrophil. This is of importance since these cells have to be under strict control to maintain good health . If deregulation occurs, this could lead to several inflammatory diseases. Therefore our work aiming at understanding the role and participation of the cytoskeleton in the physiology of neutrophils and inflammation, is important for all Canadians especially those suffering from inflammatory disorders and also workers exposed to pro-inflammatory agents (dusts, chemicals, nanoparticles, etc.), researchers, clinicians, people making risk management, etc.,