Role of the cytoskeleton in granulocyte activation and inflammation.

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The cell cytoskeleton is a dynamic structure that is targeted by several anti-cancer drugs to arrest cell proliferation. Upon stimulation, a significant re-organization of the cytoskeleton occurs in a variety of cells. The present research program focuses on one cell type of the immune system, the neutrophil that is a key player in inflammation. Especially, re-organization of the cytoskeleton occurs in activated neutrophils during different functions exerted by these cells to fight foreign pathogens. The main objective of the proposed research program is to elucidate the role of the different cytoskeletal structures in the general cell biology and physiology of the neutrophil. This is of importance since these cells have to be under strict control to maintain good health . If deregulation occurs, this could lead to several inflammatory diseases. Therefore our work aiming at understanding the role and participation of the cytoskeleton in the physiology of neutrophils and inflammation, is important for all Canadians especially those suffering from inflammatory disorders and also workers exposed to pro-inflammatory agents (dusts, chemicals, nanoparticles, etc.), researchers, clinicians, people making risk management, etc.,