Mechanism and impact of de novo centriole assembly in mammalian cells

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Centrioles dictate cell organisation and are instrumental in cell division. Centrioles replicate in S-phase, such that one pair is available to organize each pole of the mitotic spindle during cell division. Whilst replication of the existing centriole pair is the canonical mode of centriole generation, new centrioles can form ‘de-novo' if the existing centrioles are removed using lasers or microsurgery. Thus, cells have the capability to form new centrioles de novo, but very little is known about this pathway, and appropriate models for examining its mechanism are scarce.