Examining the Functional Association Between ABC Transporters and Sho1p

检查 ABC 转运蛋白和 Sho1p 之间的功能关联

• 批准号: RGPIN-2015-05314
• 负责人: Stagljar, Igor
• 金额: $ 2.19万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590353
• 关键词: Examining; Functional; Association; Between; ABC

Cells have a number of stress response mechanisms used to maintain viability in response to endogenous and environmental challenges. Examples include the High Osmolarity Glycerol (HOG) MAPK pathway in yeast (partially regulated by the Sho1p plasma membrane osmosensor) which responds to osmotic stress, and the actions of the integral membrane ABC transporters, which maintain cellular homeostasis by transporting diverse compounds (e.g. drugs, toxic metabolites etc.) across biological membranes. A better understanding of these responses is essential to expanding our knowledge of the inner workings of the cell.

细胞具有许多应激反应机制，用于维持活力以响应内源性和环境挑战。实例包括酵母中的高渗透压甘油（HOG）MAPK途径（部分由Sho1p质膜ATP传感器调节），其响应于渗透胁迫，以及整合膜ABC转运蛋白的作用，其通过转运不同的化合物（例如药物、有毒代谢物等）维持细胞内稳态。穿过生物膜更好地理解这些反应对于扩大我们对细胞内部工作的了解至关重要。