Exploring and expanding natural product chemical diversity

探索和扩大天然产物化学多样性

• 批准号: RGPIN-2015-05996
• 负责人: Wright, Gerard
• 金额: $ 4.59万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590772
• 关键词: Exploring; expanding; natural; product; chemical

Microbial secondary metabolites are genetically encoded bioactive molecules assembled by dedicated metabolic pathways that are highly regulated and tuned to environmental cues. As products of evolution, they are unique elicitor molecules that perform critical tasks for the producing organisms. Furthermore, they are rich sources of molecules that likely serve producing organisms in control of encroaching species and to gain advantage in accessing nutrients. Given their intrinsic bioactivity and physiological effects, it is not surprising that microbial natural products have served as a rich source of medicines and pest control agents for millennia and more recently as drugs and agriculturally important agents. Over the past grant period, our NSERC-funded research has enabled us to explore the production, biochemistry, ecology and engineering of microbially produced natural products.

微生物次生代谢物是基因编码的生物活性分子，由专门的代谢途径组装而成，这些途径受到高度调节并适应环境线索。作为进化的产物，它们是独特的激发子分子，为生产生物体执行关键任务。此外，它们是丰富的分子来源，可能有助于生产生物体控制入侵物种并获得获取营养的优势。 鉴于其内在的生物活性和生理效应，微生物天然产物几千年来一直作为药物和害虫防治剂的丰富来源，最近又作为药物和农业上重要的制剂，这并不奇怪。在过去的资助期内，我们的 NSERC 资助的研究使我们能够探索微生物生产的天然产品的生产、生物化学、生态学和工程。