权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Operations and Maintenance Support for the Centre for Microbial Chemical Biology

微生物化学生物学中心的操作和维护支持

基本信息

批准号：
RTI-2017-00707
负责人：
Wright, Gerard
金额：
$ 10.93万
依托单位：
McMaster University
依托单位国家：
加拿大
项目类别：
Research Tools and Instruments
财政年份：
2016
资助国家：
加拿大
起止时间：
2016-01-01 至 2017-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=616747
关键词：
Operations Maintenance Support Centre Microbial

项目摘要

The Centre for Microbial Chemical Biology (CMCB) at McMaster University provides infrastructure and service to support discovery and applied research at the interface of Chemistry and Biology. It includes equipment to support chemical research (small molecule organic synthesis, natural product purification and characterization), analysis of biological and chemical samples (metabolomics, experimental pharmacology, biophysical measurement), biological research (cell growth in BSL11 and BSL2, protein purification, enzymology), and high throughput compound screening (identification of chemical probes of biology, support for preclinical drug discovery). The CMCB is a unique facility thatsupports the research programs of 88 McMaster investigators and 595 associated trainees in addition to 19 investigators from other Canadian Universities and 6 companies. Trainees are instructed and supervised on the use of 66 individual pieces of equipment by four MSc and PhD trained staff members under the guidance of a PhD lab manager. Staff also maintain equipment, perform experiments for investigators, and provide general support for experimental setup and planning. The CMCB was founded in 2009 and has generated research published in the top journals in Chemistry and Biology (Nature, Science, Proc. Natl. Acad. Sci. USA,Nature Chem.l Biol, Nature Biotech, Nature Commun. Cell Chemical Biology, Cell Reports, Cell System, Angew. Chem. Int. Ed., ACS Chem Biol, ACS Infec. Dis, and many others), 11 patents, and served to train undergraduate, graduate, and postdoctoral researchers in interdisciplinary investigations. This Operations and Maintenance Support proposal will serve to offset costs of CMCB service and staff in support of the research programs of 105 Canadian laboratories.

麦克马斯特微生物化学生物学中心（CMCB）大学提供基础设施和服务，以支持化学界面的发现和应用研究和生物学。它包括支持化学研究的设备（小分子有机合成、天然产物纯化和表征），分析生物和化学样品（代谢组学，实验药理学，生物物理测量），生物研究（BSL 11和BSL 2中的细胞生长，蛋白质纯化、酶学）和高通量化合物筛选（鉴定生物学的化学探针，支持临床前药物发现）。CMCB 是一个独特的设施，支持88麦克马斯特的研究计划是一个独特的设施，支持88麦克马斯特的研究计划调查人员和595名相关的受训人员，以及来自加拿大其他大学和6家公司的19名调查人员。学员接受指导和监督四名接受过硕士和博士培训的人员使用66件设备在博士实验室经理的指导下，工作人员还维持设备，为研究人员进行实验，并提供一般支持用于实验设置和规划。CMCB成立于2009年，并且产生了在化学和生物学的顶级期刊上发表的研究（Nature，Science，Proc. Natl. Acad. Sci.美国、自然化学生物学、自然生物技术、自然通讯。细胞化学生物学，细胞报告，细胞系统，Angew。化学国际版，ACS Chem Biol，ACS Infec. Dis和许多其他人），11项专利，并用于培养跨学科调查的本科生，研究生和博士后研究人员。此操作和维护支持建议将用于抵消CMCB服务和工作人员的费用，以支持 105个加拿大实验室的研究项目。