Statistical physics models for the regulation of the structure of chromatin

染色质结构调控的统计物理模型

• 批准号: RGPIN-2015-06150
• 负责人: Emberly, Eldon
• 金额: $ 2.04万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590874
• 关键词: Statistical; physics; models; regulation; structure

My research program applies methods of computational physics to address the question of how physical constraints lead to complex spatial organization in a cell. It is focused on developing data driven models that draw from strong collaborations with experimental biologists. An important physical process in cell biology is the packaging of DNA into the small volume of the cell. DNA is meticulously arranged; the structure of which affects a host of cellular functions. I have two research efforts that address timely unanswered questions about this process.

我的研究项目应用计算物理学的方法来解决物理约束如何导致细胞中复杂的空间组织的问题。 它专注于开发数据驱动的模型，这些模型来自与实验生物学家的密切合作。细胞生物学中的一个重要物理过程是将DNA包装到细胞的小体积中。DNA是精心排列的，其结构影响着细胞的许多功能。 我有两项研究工作，及时解决这个过程中未回答的问题。