A genome informatics approach to discover the genetic determinants of the evolution of parasitism in nematode worms.

一种基因组信息学方法，用于发现线虫寄生进化的遗传决定因素。

• 批准号: RGPIN-2015-06239
• 负责人: Wasmuth, James
• 金额: $ 2.48万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590933
• 关键词: genome; informatics; approach; discover; genetic

Species of nematodes are ubiquitous, and significant parasites of animals and plants. This parasitism has evolved multiple times independently from free-living ancestral species. The biological mechanisms that support parasitism are encoded in the nematodes’ genomes. The long-term objectives of my research program are to understand which regions of the genome evolved, and how this leads to the origin and maintenance of the behaviour and biochemical traits that we observe in today’s parasitic nematodes. Using a combination of genomics, bioinformatics and evolutionary biology approaches, my research program examines the evolution of gene duplications and growth of gene families in the genomes of both free-living and parasitic nematodes of livestock animals. Large gene families are implicated in responding to an organism’s response to its environment. Changes in these gene families frequently correlate to the adaptation of a new environment, which can lead to the emergence of a new species. The fully sequenced genomes of over 20 nematode species of interest –

线虫是动植物中普遍存在的重要寄生虫。这种寄生已经独立于自由生活的祖先物种进化了好几次。支持寄生的生物机制编码在线虫的基因组中。我研究计划的长期目标是了解基因组的哪些区域进化，以及这如何导致我们在当今寄生线虫中观察到的行为和生化特征的起源和维持。我的研究项目结合了基因组学、生物信息学和进化生物学的方法，研究了家畜自由生活线虫和寄生线虫基因组中基因复制的进化和基因家族的增长。大的基因家族与有机体对其环境的反应有关。这些基因家族的变化往往与新环境的适应相关，这可能导致新物种的出现。对20多种感兴趣的线虫物种的全基因组测序-