AnVIL Clinical Environment for Innovation and Translation (ACE-IT)
AnVIL Clinical Environment for Innovation and Translation (ACE-IT)
批准号:
10747551
负责人:
Robert J Carroll
金额:
$149.44万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-08-21 至 2028-05-31
关键词:
Academic Medical CentersAccelerationAddressAdoptedAdoptionAll of Us Research ProgramAmerican Heart AssociationBiomedical ResearchBreast Cancer Risk FactorCancer ControlCapitalClinicalClinical ResearchCloud ComputingCollaborationsCollectionCommunitiesComplexCost ControlDataData ScienceData SetDevelopmentDiagnosisDiseaseEcosystemElectronic Medical Records and Genomics NetworkEnvironmentEquityFamilyFoundationsFundingGeneral HospitalsGenomeGenomicsGrowthHealthHealth Disparities ResearchHealth ResourcesHealthcareHospitalsIndividualInformaticsInfrastructureIngestionInvestmentsKnowledgeLibrariesMassachusettsMethodsMissionNational Human Genome Research InstituteOutcomePatient CarePersonsPharmacogenomicsPopulationPopulation HeterogeneityProcessRare DiseasesRecording of previous eventsResearchResearch MethodologyResearch PersonnelResourcesRiskRisk AssessmentRisk FactorsSecurityServicesStreamSystemTechnologyTimeTraining SupportTranslational ResearchTranslationsUnited States National Institutes of HealthVisualizationWomanWorkcancer preventioncloud basedcomputational platformcomputing resourcesdata integrationdata resourcedata spacedesigndisease diagnosisdiverse dataevidence basegenome resourcegenome sciencesgenomic datagenomic toolshazardhealth care settingsimprovedindexinginformatics toolinnovationmeetingsmembernew technologynovelphenotypic datapolygenic risk scoresocial health determinantssupport toolstooltranslational approachtranslational genomicsworking group
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
The Analysis, Visualization, and Informatics Lab-space (AnVIL) platform is a scalable cloud-based
computing resource that aims to accelerate genomics research by providing broad access to
genomics datasets and the infrastructure necessary to improve analysis workflows and enhance
collaboration. The AnVIL Clinical Environment for Innovation and Translation (ACE-IT)
project will bring together a network of expertise to address a major gap in clinical genomics
research and operationalize a key mission of the AnVIL project by expanding its existing
ecosystem to include a comprehensive suite of clinical genomics research tools and services.
The newly developed AnVIL Clinical Resource will bring together data, tools, and support
resources meant to amplify the benefits of the existing platform and provide a critical foundation
for the clinical genomics research community to better leverage this innovative resource.
Development of the ACE-IT will be guided by three key aims: 1. Engagement with diverse
community and research partners to characterize barriers and facilitators to adopting federally-
supported, cloud-connected clinical genomics research services; 2. Development and
deployment approaches to ingest, index, and search data to support clinical genomics research
with an emphasis on populations historically underrepresented in biomedical research; and 3.
Integration of tools, APIs, and workflows that enable clinical genomics research methods on the
AnVIL, including rare disease diagnosis and genomic risk scores as use cases. The ACE-IT team
consists of expertise across multiple health care centers, including Vanderbilt University Medical
Center, Brigham and Women's Hospital, Massachusetts General Hospital, and the American
Heart Association. This team will develop infrastructure on AnVIL's cloud environment to meet
clinical genomics researchers' needs over time and integrate with existing AnVIL working groups
and meetings as team members and stakeholders where appropriate. The tools and resources
we develop will support clinical genomics research by focusing on both rare and common
diseases and integration into translational research.
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Data Management and Portal for the INCLUDE (DAPI) Project
-
批准号:10697338
-
项目类别:
-
资助金额:$386.95万
-
财政年份:2020
-
负责人:Robert J Carroll
-
依托单位:
Data Management and Portal for the INCLUDE (DAPI) Project
-
批准号:10264912
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项目类别:
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资助金额:$386.95万
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财政年份:2020
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负责人:Robert J Carroll
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依托单位:
Advancing Image Data Interoperability and Standards within an NIH Ecosystem (AIDISNE): A CHOP, FlyWheel, and Seven Bridges Integration Demonstration Project
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批准号:10690302
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项目类别:
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资助金额:$91.19万
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财政年份:2020
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负责人:Robert J Carroll
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依托单位:
User-ready tools and scalable workflows for INCLUDE datasets in the cloud: advancing brain imaging data management and analytics
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批准号:10406678
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项目类别:
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资助金额:$27.36万
-
财政年份:2020
-
负责人:Robert J Carroll
-
依托单位:
Data Management and Portal for the INCLUDE (DAPI) Project
-
批准号:10472037
-
项目类别:
-
资助金额:$386.95万
-
财政年份:2020
-
负责人:Robert J Carroll
-
依托单位:
The AnVIL Data Ecosystem
-
批准号:10222996
-
项目类别:
-
资助金额:$50.0万
-
财政年份:2018
-
负责人:Robert J Carroll
-
依托单位:
The AnVIL Data Ecosystem
-
批准号:10231107
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项目类别:
-
资助金额:$450.0万
-
财政年份:2018
-
负责人:Robert J Carroll
-
依托单位:
The AnVIL Data Ecosystem
-
批准号:10406082
-
项目类别:
-
资助金额:$98.3万
-
财政年份:2018
-
负责人:Robert J Carroll
-
依托单位:
The AnVIL Data Ecosystem
-
批准号:9788512
-
项目类别:
-
资助金额:$495.45万
-
财政年份:2018
-
负责人:Robert J Carroll
-
依托单位:
The AnVIL Data Ecosystem
-
批准号:10166400
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项目类别:
-
资助金额:$21.72万
-
财政年份:2018
-
负责人:Robert J Carroll
-
依托单位:
The AnVIL Data Ecosystem DACReS Supplement
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批准号:10365770
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项目类别:
-
资助金额:$11.28万
-
财政年份:2018
-
负责人:Robert J Carroll
-
依托单位:
The AnVIL Data Ecosystem
-
批准号:10472503
-
项目类别:
-
资助金额:$450.0万
-
财政年份:2018
-
负责人:Robert J Carroll
-
依托单位:
Enhancing CBTN digital pathology processing pipeline through the use AWS cloud-based services to enable automation, parallel processing, and rapid use of AI/ML analytics
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批准号:10827712
-
项目类别:
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资助金额:$28.22万
-
财政年份:2017
-
负责人:Robert J Carroll
-
依托单位:
Gabriella Miller Kids First Pediatric Data Resource Center: Advancing Collaborative Platform-Enabled Data-Driven Discovery at the Intersection of Childhood Development and Cancer
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批准号:10707964
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项目类别:
-
资助金额:$400.0万
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财政年份:2017
-
负责人:Robert J Carroll
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依托单位:
KF Supplement -- Sustainable and Optimized Cloud Resources on behalf of the Kids First Data Resources
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批准号:10888770
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项目类别:
-
资助金额:$50.0万
-
财政年份:2017
-
负责人:Robert J Carroll
-
依托单位:
Gabriella Miller Kids First Pediatric Data Resource Center: Advancing Collaborative Platform-Enabled Data-Driven Discovery at the Intersection of Childhood Development and Cancer
-
批准号:10513120
-
项目类别:
-
资助金额:$400.0万
-
财政年份:2017
-
负责人:Robert J Carroll
-
依托单位:
海外基金