Characterization and role of the Drug / Metabolite Transporter (DMT) superfamily in drug resistance using a bodonid kinetoplastid model

对寄生虫病的研究创造了许多机会和挑战，因为人类和牲畜中的所有寄生虫感染都是通过使用药物来控制的。这些药物已经持续使用，在某些情况下超过60年，因此已经产生了耐药性或耐受性。由于疫苗（目前）不是许多此类感染的可行选择，因此药物是控制规划的主要手段。对于大多数寄生虫病，迫切需要开发新的和更好的药物，但为了做到这一点，有必要提高对耐药性的了解，试图绕过或克服它，并寻找寄生虫的新的特定细胞靶点。该研究计划的长期目标是了解寄生生物耐药的机制。为了实现这一目标，在未来五年内

Study of parasitic diseases creates a number of opportunities and challenges as all parasitic infections in humans and livestock are controlled by the use of drugs. These drugs have been in continuous use, in some cases for over 60 years, and as such a resistance or tolerance has developed. Since vaccines are not a viable option (at present) for many of these infections, drugs are the mainstay of control programs. For most parasitic diseases, there is an urgent need to develop new and better drugs but to do this an improved understanding of drug resistance, to try to circumvent or overcome it, and the search for new specific cellular targets of parasites are warranted. The long term objective of the research program is to understand the mechanism(s) of drug resistance in parasitic organisms. Towards realizing that goal, over the next five years the