Characterization and role of the Drug / Metabolite Transporter (DMT) superfamily in drug resistance using a bodonid kinetoplastid model

使用 bodonid 动质体模型表征药物/代谢物转运蛋白 (DMT) 超家族在耐药性中的作用

• 批准号: RGPIN-2015-06317
• 负责人: Ardelli, Bernadette
• 金额: $ 2.19万
• 依托单位: Brandon University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629778
• 关键词: Characterization; role; Drug; Metabolite; Transporter

Study of parasitic diseases creates a number of opportunities and challenges as all parasitic infections in humans and livestock are controlled by the use of drugs. These drugs have been in continuous use, in some cases for over 60 years, and as such a resistance or tolerance has developed. Since vaccines are not a viable option (at present) for many of these infections, drugs are the mainstay of control programs. For most parasitic diseases, there is an urgent need to develop new and better drugs but to do this an improved understanding of drug resistance, to try to circumvent or overcome it, and the search for new specific cellular targets of parasites are warranted. The long term objective of the research program is to understand the mechanism(s) of drug resistance in parasitic organisms. Towards realizing that goal, over the next five years the

寄生虫病的研究创造了许多机会和挑战，因为人类和牲畜的所有寄生虫感染都是通过使用药物来控制的。这些药物一直在持续使用，在某些情况下超过60年，因此产生了耐药性或耐受性。由于疫苗不是一个可行的选择（目前）对许多这些感染，药物是主要的控制计划。对于大多数寄生虫病，迫切需要开发新的和更好的药物，但要做到这一点，需要提高对耐药性的理解，试图规避或克服它，并寻找寄生虫的新的特异性细胞靶点。该研究计划的长期目标是了解寄生生物的耐药性机制。为了实现这一目标，在未来五年内，