Transcranial Magnetic Stimulation System

经颅磁刺激系统

• 批准号: RTI-2016-00051
• 负责人: Staines, William
• 金额: $ 5.88万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=591326
• 关键词: Transcranial; Magnetic; Stimulation; System

Non-invasive brain stimulation techniques are essential for understanding neural mechanisms associated with neuroplasticity in the central nervous system (CNS). Neuroplasticity is the foundation for adaptation in the CNS associated with experience-dependent learning, sensori-motor integration and in the restoration of function following nervous system injury. Transcranial magnetic stimulation (TMS) is an effective, non-invasive brain stimulation method that involves passing current through a stimulator coil that generates a magnetic field perpendicular to the current flow. The magnetic field passes through the bone of the skull unimpeded and excites neurons in the cerebral cortex. Dr. Staines currently has a TMS unit (Medtronic / Magventure MagPro x100) that is reaching the end of its recommended lifespan (~ 10 years). The stimulation coils also require replacement every ~3-5 years. There are 2 specific coils required that allow stimulation in different frequency patterns. Such stimulation can be done with single or paired-pulse configurations to the cerebral cortex or in a repetitive mode requiring multiple stimuli to be delivered over a short time frame. One such pattern is termed theta burst stimulation (TBS) in which stimuli are delivered in burst patterns of 3 stimuli at 50 Hz delivered at a frequency of 5 Hz (theta) over a short period of time. This TBS can be delivered in different modes to either transiently excite or depress a specific area of the brain. The present request is for replacement of the current TMS system (MagPro) including 2 stimulation coils and replacement electroencephalography (EEG) caps to integrate with our current TMS and EEG (SynAmps2, Neuroscan, Compumedics) systems. This will allow the quantification of neuromodulation induced by the TMS both within and across individuals to be greatly enhanced. This is critical for studies of the neural mechanisms associated with sensorimotor neuroplasticity, cognitive neuroscience and oculomotor processes. The equipment will allow the continuation of ongoing work as well as the development of new collaborative teams. HQP from several Faculties (AHS, Science, Arts) will have access to training and use of the equipment.

非侵入性脑刺激技术对于理解中枢神经系统（CNS）中与神经可塑性相关的神经机制至关重要。神经可塑性是与经验依赖性学习、感觉-运动整合相关的CNS适应的基础，也是神经系统损伤后功能恢复的基础。经颅磁刺激（TMS）是一种有效的非侵入性脑刺激方法，其涉及使电流通过刺激器线圈，该刺激器线圈产生垂直于电流流动的磁场。磁场畅通无阻地穿过头骨，并刺激大脑皮层中的神经元。Dr.斯泰内斯目前有一台TMS装置（Medtronic / Magventure MagPro x100），即将达到其推荐使用寿命（约10年）。刺激线圈也需要每3-5年更换一次。需要2个特定线圈，以允许不同频率模式的刺激。这种刺激可以通过对大脑皮层的单脉冲或成对脉冲配置来完成，或者以需要在短时间帧内递送多个刺激的重复模式来完成。一种这样的模式被称为θ脉冲串刺激（TBS），其中刺激以在短时间段内以5 Hz（θ）的频率递送的50 Hz的3个刺激的脉冲串模式递送。这种TBS可以以不同的模式传递，以短暂地兴奋或抑制大脑的特定区域。本申请旨在更换当前TMS系统（MagPro），包括2个刺激线圈和更换脑电图（EEG）帽，以与我们当前的TMS和EEG（SynAmps 2，Neuroscan，Compumedics）系统集成。这将允许大大增强个体内和个体间由TMS诱导的神经调节的量化。这对于与感觉运动神经可塑性、认知神经科学和动眼过程相关的神经机制的研究至关重要。这些设备将使正在进行的工作得以继续，并使新的协作小组得以发展。来自多个学院（AHS、理科、文科）的HQP将有机会接受培训并使用设备。