Novel Brain-Chip Technology Development for Mammalian Neurons

哺乳动物神经元的新型脑芯片技术开发

• 批准号: RTI-2016-00573
• 负责人: Syed, Naweed
• 金额: $ 10.89万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=591492
• 关键词: Novel; Brain; Chip; Technology; Development

Our research program is focused on developing novel neuron-chip and nerve-electronic conduit technologies that enable better understanding of brain function and to ensure future development of neuro-prosthesis. These novel technologies also hold tremendous potential for commercialization, which will boost Canadian economy. Specifically, we have developed four novel technologies in partnership with the Max Plank Institute (Germany – the neuro-chip), NRC (Ottawa – the patch clamp chip), Lab on Chip (Schulich School of Engineering) and a dopamine detection chip (UK). All of these technologies took advantage of large invertebrate neurons, which are easily accessible at the level of single cells and can be manipulated on these chips with great ease. Moreover, these snail neurons do not require oxygenation and temperature regulations. To advance our technology development for commercialization further, we need to explore their potential for long-term recordings from vertebrate neurons. To achieve this, we require an inverted microscope along with mounted incubator (CO

我们的研究项目专注于开发新型神经芯片和神经电子导管技术，使人们能够更好地了解大脑功能，并确保神经假体的未来发展。这些新技术也具有巨大的商业化潜力，这将促进加拿大经济的发展。具体来说，我们与马克斯普朗克研究所（德国-神经芯片），NRC（渥太华-膜片钳芯片），芯片实验室（Schulich工程学院）和多巴胺检测芯片（英国）合作开发了四项新技术。所有这些技术都利用了大型无脊椎动物神经元，这些神经元在单细胞水平上很容易获得，并且可以在这些芯片上轻松操作。此外，这些蜗牛神经元不需要氧合和温度调节。为了进一步推进我们的技术开发以实现商业化，我们需要探索它们在脊椎动物神经元长期记录方面的潜力。为了实现这一点，我们需要一个倒置显微镜沿着安装培养箱（CO