Redox stress and neuronal functions

氧化还原应激和神经元功能

• 批准号: 227168-2013
• 负责人: RAMASSAMY, Charles
• 金额: $ 1.82万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594053
• 关键词: Redox; stress; neuronal; functions

The non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs) produced a broad range of oxidation products or oxylipidome including many aldehydes, isoprostanes, isoketals, neuroprostanes, and 4-HNE. These products have been widely detected in different biological fluids and tissue samples to evidence lipoperoxidation and oxidative stress. Among them, many members are electrophilic and reactive, capable of modifying nucleophilic sites on proteins to form stable covalent adducts. They are, therefore, called the reactive lipid species (RLS). Our work and others showed that RLS can modify a subset of proteins, called the electrophile-reponsive proteome, which, in concert orchestrate biological response such as proteins associated with signal transduction, mitochondrial respiration and cell death or survival pathways.

多不饱和脂肪酸 (PUFA) 的非酶氧化产生了多种氧化产物或氧化脂质，包括许多醛、异前列烷、异缩酮、神经前列腺素和 4-HNE。这些产品已在不同的生物体液和组织样本中广泛检测，以证明脂过氧化和氧化应激。其中，许多成员具有亲电性和反应性，能够修饰蛋白质上的亲核位点，形成稳定的共价加合物。因此，它们被称为活性脂质（RLS）。我们和其他人的工作表明，RLS 可以修饰蛋白质的一个子集，称为亲电反应蛋白质组，它可以协调生物反应，例如与信号转导、线粒体呼吸和细胞死亡或生存途径相关的蛋白质。