Patterned Hydrogel Matrix for Three-Dimensional Cell Growth

用于三维细胞生长的图案化水凝胶基质

• 批准号: 312191-2012
• 负责人: Cao, Xudong
• 金额: $ 1.46万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=595066
• 关键词: Patterned; Hydrogel; Matrix; Three; Dimensional

Polymeric biomaterials have been widely used with great success for applications in regenerative medicine, particularly in tissue engineering and drug delivery. The proposed research program at the University of Ottawa will specifically be targeted to use polymeric biomaterials to influence cell biology for applications in spinal cord injury repairs. The research program proposes a novel photocaged peptide approach to combine material science and engineering with biology. The objective of this project is to optimize the novel photocage approach that my lab has recently developed in order guide neuronal growth in 3D hydrogel. Ultimately, our goal is to overcome spinal cord injuries and anticipate that the fundamental knowledge created in the proposed research program will lead to strategies in regenerative medicine to overcome other central nervous system disorders such as brain injuries where regeneration is critical.

聚合物生物材料已广泛应用于再生医学，特别是在组织工程和药物输送方面取得了巨大的成功。渥太华大学拟议的研究计划将专门针对使用聚合物生物材料来影响细胞生物学，以应用于脊髓损伤修复。该研究计划提出了一种新的光笼多肽方法，将材料科学和工程与生物学结合起来。这个项目的目的是优化我的实验室最近开发的新的光笼方法，以指导神经元在3D水凝胶中的生长。最终，我们的目标是克服脊髓损伤，并预计在拟议的研究计划中创造的基础知识将导致再生医学的战略，以克服其他中枢神经系统疾病，如脑损伤，再生是关键的。