DEVELOPMENTAL CHANGES IN CORTICAL FUNCTION AND ORGANIZATION DURING MIDDLE CHILDHOOD

中年时期皮质功能和组织的发育变化

• 批准号: 418619-2013
• 负责人: Hall, Geoffrey
• 金额: $ 2.11万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596443
• 关键词: DEVELOPMENTAL; CHANGES; CORTICAL; FUNCTION; ORGANIZATION

Dramatic advances in cognitive and emotional capacities of children take place during middle childhood. The proposed programme of research is aimed at discovering the structural and functional brain changes that underlie these improvements. We will use MRI to examine the brains of children age 7 to 10 years. Children will be scanned twice at two-year intervals in this longitudinal study. The study participants are being recruited from a of group children that are part of a larger study that has run for last 7 years. We will examine changes the connections of brain networks, both structurally by looking at white matter tracts, and functionally, by looking at brain activation patterns. We will explore age related changes in the networks responsible for cognitive processes like memory and inhibition. In addition, we will examine the role of these networks in emotional regulation. MRI tasks and developmental measures have been designed to be engaging and sensitive to differences in cognitive capacities. The research will yield novel and much needed information about typical child development at both behavioural and brain levels and will lay the groundwork for future research examining a number of environmental and genetic influences on brain development.

儿童在认知和情感能力方面的显著进步发生在童年中期。拟议的研究计划旨在发现这些改进背后的大脑结构和功能变化。我们将使用核磁共振检查7到10岁儿童的大脑。在这项纵向研究中，儿童将每两年接受两次扫描。研究参与者是从一组儿童中招募的，这是过去7年进行的一项更大研究的一部分。我们将研究大脑网络连接的变化，通过观察白质束的结构，以及通过观察大脑激活模式的功能。我们将探索负责记忆和抑制等认知过程的网络中与年龄相关的变化。此外，我们将研究这些网络在情绪调节中的作用。MRI任务和发展措施的设计是参与和敏感的认知能力的差异。这项研究将在行为和大脑两个层面上产生关于典型儿童发育的新颖和急需的信息，并将为未来研究环境和遗传对大脑发育的影响奠定基础。