Neurodevelopmental changes in brain structure and function across middle childhood

童年中期大脑结构和功能的神经发育变化

• 批准号: RGPIN-2019-06860
• 负责人: Hall, Geoffrey
• 金额: $ 2.4万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=764335
• 关键词: Neurodevelopmental; changes; brain; structure; function

The proposed programme of research is aimed at discovering the structural and functional brain changes that underlie the advances in cognitive and emotional capacities of children during middle childhood. The brain is organized into networks that consist of individual regions that collaborate to perform diverse cognitive functions. Magnetic Resonance Imaging can provide information about the brain both structurally, by examining white matter tracts and functionally, by looking at brain activation patterns. We plan utilize a large imaging data repository and to apply methods that combine these two information sources to yield an anatomically weighted measure of functional connectivity. In addition, we will make use of a novel dual-task fMRI paradigm involving emotion regulation and response inhibition. We have a cohort of children that have been scanned at age 7 years and over the next 4 years will be rescanned when they turn 13 years of age. We use information gained from the analysis of repository data to guide our dual-task analyses. Furthermore, will examine age related changes in the networks responsible for cognitive control and emotional regulation. Here we advance the theory that improvements in emotional regulation capacities are tied developmentally to the consolidation of network structures involved in cognitive control. Our MRI tasks and developmental measures have been designed to be engaging and sensitive to differences in cognitive / emotional processing capacities. The research will yield novel and much needed information about typical child development at both behavioural and brain levels. The study is longitudinal and therefore promises to provide valuable information about normal developmental trajectories of networks. In addition, very few studies to date have made combined use of functional and structural MRI connectivity measures to examine brain changes during childhood. This work offers to advance current methods of anatomically weighted functional connectivity analyses. Finally, this research will lay the groundwork for future research examining a number of environmental and genetic influences on brain development.

拟议的研究方案旨在发现儿童在童年中期认知和情感能力进步的基础上的大脑结构和功能变化。大脑被组织成由各个区域组成的网络，这些区域相互协作，执行不同的认知功能。磁共振成像可以通过检查白质束在结构上和功能上通过观察大脑激活模式来提供关于大脑的信息。我们计划利用一个大型成像数据库，并应用将这两个信息源结合在一起的方法，以产生功能连接性的解剖学加权测量。此外，我们将利用一种新的双任务功能磁共振成像范式，涉及情绪调节和反应抑制。我们有一批儿童在7岁时接受了扫描，在接下来的4年里，当他们13岁时将重新扫描。我们使用从存储库数据分析中获得的信息来指导我们的双重任务分析。此外，还将研究负责认知控制和情绪调节的网络中与年龄相关的变化。在这里，我们提出的理论是，情绪调节能力的提高与认知控制所涉及的网络结构的巩固在发展上是联系在一起的。我们的核磁共振任务和发展措施被设计成参与并对认知/情绪处理能力的差异敏感。这项研究将在行为和大脑层面上提供关于典型儿童发育的新的和亟需的信息。这项研究是纵向的，因此有望提供有关网络正常发展轨迹的有价值的信息。此外，到目前为止，很少有研究结合使用功能和结构磁共振连通性测量来检查儿童时期的大脑变化。这项工作为改进当前的解剖学加权功能连通性分析方法提供了参考。最后，这项研究将为未来考察环境和基因对大脑发育的影响的研究奠定基础。