Developmental control of C. elegans germline syncytial organization and function

线虫种系合胞体组织和功能的发育控制

• 批准号: 434942-2013
• 负责人: Labbé, JeanClaude
• 金额: $ 3.59万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596637
• 关键词: Developmental; control; C.; elegans; germline

Cytokinesis is the final step of cell division and consists in the physical separation of a mother cell into two individual daughter cells. As such, it is highly regulated and its failure can have dramatic consequences on an organism's development and tissue homeostasis. Interestingly, certain cell types, such as human liver cells, undergo controlled cytokinesis failures to form so-called syncytia, in which multiple nuclei remain connected to one another and function together in a tissue. Studying how cells control such cytokinesis failures may provide useful information to decipher the critically regulated steps that are required during normal cytokinesis, but also to better understand how syncytial tissues and organs are formed during animal development.

胞质分裂是细胞分裂的最后一步，包括母细胞物理分离成两个单独的子细胞。因此，它是高度调节的，它的失败可能对生物体的发育和组织稳态产生巨大的后果。有趣的是，某些细胞类型，如人类肝细胞，经历受控的胞质分裂失败，形成所谓的合胞体，其中多个细胞核保持相互连接，并在组织中一起发挥作用。研究细胞如何控制这种胞质分裂失败可能提供有用的信息，以破译在正常胞质分裂过程中所需的关键调节步骤，也可以更好地了解合胞体组织和器官是如何在动物发育过程中形成的。