Generating Innate Immune Diversity to Recognize Newly Emerging Pathogens

产生先天免疫多样性以识别新出现的病原体

• 批准号: 436250-2013
• 负责人: Palaniyar, Nades
• 金额: $ 2.19万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596898
• 关键词: Generating; Innate; Immune; Diversity; Recognize

Overview: Emergence of new and drug-resistant pathogens is a reality. Most of these pathogens contain thick carbohydrate coats that are rarely recognized by our classical antibodies (e.g., IgG). However, innate immune collectins are anti-carbohydrate antibody-like molecules, and readily recognize a range of microbes. We will determine whether tissue inflammation induces mutation in collectins such as lung surfactant proteins A and D (SP-A, SP-D), so that the mutant proteins can recognize and neutralize newly emerging pathogens. This mechanism could give an evolutionary advantage to the host animals and humans.

概述：新的耐药病原体的出现是一个现实。这些病原体中的大多数含有很厚的碳水化合物外壳，这些外壳很少被我们的经典抗体识别（例如，IgG）。然而，先天性免疫凝集素是抗碳水化合物抗体样分子，并且容易识别一系列微生物。我们将确定组织炎症是否会诱导肺表面活性蛋白A和D（SP-A，SP-D）等聚集素突变，以便突变蛋白能够识别和中和新出现的病原体。这种机制可以为宿主动物和人类提供进化优势。