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Regulation of mRNA stability and translation during human neurodevelopment

Regulation of mRNA stability and translation during human neurodevelopment
人类神经发育过程中 mRNA 稳定性和翻译的调节
批准号:
345198
负责人:
Ellis James R
金额:
$41.77万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-03-01 至 2019-03-01

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中文摘要
翻译
Rett综合征和自闭症谱系障碍(ASD)会影响大脑回路的发育。Rett综合征是由MECP2基因突变引起的,而ASD则与数百种不同基因的突变有关。基因通过制造RNA来发挥作用
英文摘要
Development of brain circuitry is affected in Rett syndrome and Autism Spectrum Disorder (ASD). Rett syndrome is caused by mutations in the MECP2 gene while ASD is associated with mutations in hundreds of different genes. Genes function by making RNA that
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Canada Research Chair - Tier 1
  • 批准号:
    454005
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2021
  • 负责人:
    Ellis James R
  • 依托单位:
Post-transcriptional regulation of functionally significant gene sets during neurodevelopment of Rett syndrome
  • 批准号:
    409282
  • 项目类别:
    Operating Grants
  • 资助金额:
    $66.6万
  • 财政年份:
    2019
  • 负责人:
    Ellis James R
  • 依托单位:
Identification of converging Molecular Pathways Across Chromatinopathies as Targets for Therapy: IMPACT
  • 批准号:
    387180
  • 项目类别:
    Operating Grants
  • 资助金额:
    $27.32万
  • 财政年份:
    2018
  • 负责人:
    Ellis James R
  • 依托单位:
MECP2 function and rescue in neurons derived from Rett syndrome patient iPS cells
  • 批准号:
    290906
  • 项目类别:
    Operating Grants
  • 资助金额:
    $33.15万
  • 财政年份:
    2013
  • 负责人:
    Ellis James R
  • 依托单位:
海外基金