Developing and optimizing cell lines to study and control emerging viral diseases in farmed Atlantic Salmon: the HSMI and PRV case

开发和优化细胞系以研究和控制养殖大西洋鲑鱼中新出现的病毒性疾病：HSMI 和 PRV 案例

• 批准号: 468298-2014
• 负责人: Bols, Niels
• 金额: $ 8.6万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=598265
• 关键词: Developing; optimizing; cell; lines; study

Fish represent one of the most healthy sources of food in the world; yet, capture fisheries are declining. In the future, aquaculture will likely supply most fish. As a result, fish farming has become a valuable economic activity, but maintaining aquaculture is challenging. One challenge is emerging viral diseases. An example for Atlantic salmon (AS) is heart and skeletal muscle inflammation (HSMI). The causative agent is thought to be piscine reovirus (PRV). PRV reproduces only marginally in vitro and only in 1 cell line, preventing easy diagnosis, virus isolation and vaccine preparation.

鱼类是世界上最健康的食物来源之一;然而，捕捞渔业正在下降。在未来，水产养殖可能会提供大多数鱼类。因此，鱼类养殖已成为一项有价值的经济活动，但维持水产养殖业具有挑战性。一个挑战是新出现的病毒性疾病。大西洋鲑鱼（AS）的一个例子是心脏和骨骼肌炎症（HSMI）。病原体被认为是鱼呼肠孤病毒（PRV）。PRV在体外仅少量繁殖，且仅在1个细胞系中繁殖，妨碍了诊断、病毒分离和疫苗制备的容易性。