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Characterization of the proteostasis decline upon aging

Characterization of the proteostasis decline upon aging
衰老时蛋白质稳态下降的特征
批准号：
342392
负责人：
Mayor Thibault
金额：
$48.73万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-03-01 至 2021-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=342392&lang=en
关键词：
Aggregation Aging Chaperone Heat Shock Proteins (Hsps) Mass Spectrometry Oxidation Protein Folding Protein Homeostasis Proteomics Ubiquitin

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中文摘要
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英文摘要
Aging is a complex process characterized by a progressive decline of the ability of tissues to retain their functional integrity. At the cellular level, aging has been associated to a reduced capacity to maintain the integrity of the proteome (which is th
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