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Elucidation of the client repertoires and functions of the two related DNAJB6 and B8 co-chaperones

Elucidation of the client repertoires and functions of the two related DNAJB6 and B8 co-chaperones
阐明两个相关 DNAJB6 和 B8 共伴侣的客户库和功能
批准号:
477791
负责人:
Mayor Thibault
金额:
$73.29万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-03-01 至 2028-03-01

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中文摘要
翻译
蛋白质通常需要采用特定的三维构象来获得功能。不能达到或保持正确的构象是有害的,因为蛋白质有聚集的倾向。因此,有大量的不同
英文摘要
Proteins typically need to adopt a specific three-dimensional conformation to gain functionality. Failure to reach or maintain the proper conformation is deleterious, as proteins have then the tendency to aggregate. Therefore, a large number of different
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会议论文
Characterization of quality control pathways that target cytosolic misfolded proteins with missense mutations for proteasome degradation
  • 批准号:
    379590
  • 项目类别:
    Operating Grants
  • 资助金额:
    $53.22万
  • 财政年份:
    2018
  • 负责人:
    Mayor Thibault
  • 依托单位:
Characterization of the proteostasis decline upon aging
  • 批准号:
    342392
  • 项目类别:
    Operating Grants
  • 资助金额:
    $48.73万
  • 财政年份:
    2016
  • 负责人:
    Mayor Thibault
  • 依托单位:
Deciphering Protein Quality Control Pathways Targeting Cytosolic Proteins for Proteasome Degradation
  • 批准号:
    279177
  • 项目类别:
    Operating Grants
  • 资助金额:
    $62.73万
  • 财政年份:
    2013
  • 负责人:
    Mayor Thibault
  • 依托单位:
Characterization of the formation of protein aggregates induced by the inhibition of the ubiquitin proteasome system
  • 批准号:
    213396
  • 项目类别:
    Salary Programs
  • 资助金额:
    $21.86万
  • 财政年份:
    2010
  • 负责人:
    Mayor Thibault
  • 依托单位:
海外基金