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Characterization of the formation of protein aggregates induced by the inhibition of the ubiquitin proteasome system

Characterization of the formation of protein aggregates induced by the inhibition of the ubiquitin proteasome system
泛素蛋白酶体系统抑制诱导的蛋白质聚集体形成的表征
批准号：
213396
负责人：
Mayor Thibault
金额：
$21.86万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Salary Programs
财政年份：
2010
资助国家：
加拿大
项目状态：
已结题
起止时间：
2010-09-01 至 2015-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=213396&lang=en
关键词：
Chemical Biology Huntington Disease Mass Spectrometry Misfolding Neurodegenerative Disease Proteasome Protein Aggregate Ubiquitin

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中文摘要
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英文摘要
Protein aggregation is a pathological feature of a large number of diseases with a strong preponderance in age-related neurodegenerative disorders like Huntington's disease. Failure to eliminate aberrant proteins plays a major role in these pathologies an
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