Biosensor development for mycotoxins

霉菌毒素生物传感器的开发

• 批准号: 479808-2015
• 负责人: DeRosa, Maria
• 金额: $ 3.16万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=599953
• 关键词: Biosensor; development; mycotoxins

Unsafe levels of contaminants in food and feed requires new technology for the detection of these compounds along the food continuum from production to consumption. One particularly concerning class of naturally occurring compounds that can contaminate food products are mycotoxins, toxic fungal secondary metabolites. While traditional analytical techniques exist for the detection of mycotoxins, there is still an urgent need for simpler, more rapid, and cost-effective approaches to mycotoxin testing. Biosensors consist of a specific molecular recognition probe targeting an analyte of interest and a means of converting that recognition event into a measurable signal. As molecular recognition is the foundation of biosensing, there has been increased focus on the development of new molecular recognition probes for food-safety monitoring. Because of their in vitro selection and production, the relatively new technology of aptamers is emerging as a viable alternative for

食品和饲料中污染物的不安全水平需要新的技术来检测这些化合物沿着从生产到消费的食品连续体。一种特别令人关注的能够污染食品的天然存在的化合物是真菌毒素，有毒的真菌次级代谢产物。虽然存在传统的分析技术用于检测真菌毒素，但仍然迫切需要更简单，更快速，更具成本效益的真菌毒素检测方法。生物传感器由靶向感兴趣的分析物的特异性分子识别探针和将该识别事件转化为可测量信号的手段组成。由于分子识别是生物传感的基础，因此开发用于食品安全监测的新型分子识别探针越来越受到关注。由于它们的体外选择和生产，相对较新的适体技术正在成为一种可行的替代方案，