Reducing hospital acquired infections: elucidating the biocidal properties and mechanisms of novel copper containing materials

减少医院获得性感染：阐明新型含铜材料的杀菌特性和机制

• 批准号: 493795-2016
• 负责人: Aucoin, Marc
• 金额: $ 1.82万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=602864
• 关键词: Reducing; hospital; acquired; infections; elucidating

Aereus Technologies (Aereus), is an Ontario-based innovative company incorporated in 2009 that is commercializing Aereus Shield. Their patented process produces a durable, attractive coating proven to kill harmful bacteria on contact. In Canada, Aereus Shield is marketed as an antimicrobial for use exclusively on Class I and Class II medical devices. Their coating provides a cost-effective intervention against common hospital pathogens and is an ideal solution for high touch public surface. However, microbial pathogens are not the only microbes of concern. Viruses can survive on surfaces and can lead to the spread of infection in high risk settings such as hospitals. Through this grant, a greater understanding of the mechanisms at play in the interaction between two prototypical viruses and novel material coatings prepared by Aereus. The two prototypical viruses, Influenza and Adenovirus, represent two broad classes of viruses, namely enveloped and nonenveloped viruses, and will serve as the basis to initiate a relationship between Aereus and the Aucoin Lab at the University of Waterloo. Together, Aereus and Aucoin will tackle the problem of nosocomial infections by first deepening an understanding of Aereus materials and then utilizing this understanding to better design novel products. Specifically, Aucoin will be setting up a well-controlled environmental chamber in which factors such as temperature and humidity can be controlled and isolated from the biocidal properties of the Aereus materials. These materials are primarily copper-based and present themselves as coatings on metal substrates, as powders and as polymeric composites. The Aucoin group will focus on the coatings and powder in a first part before extending their findings to the analysis of the polymeric composites. Aucoin's work on the stability and quantification of viruses is properly suited to aid Aereus position itself as a unique producer of biocidal materials. Aereus is in a position to capitalize on the scientific findings given existing commercial agreements for their coatings exhibiting anti-microbial properties.

Aereus Technologies(Aereus)是一家总部位于安大略省的创新公司，成立于2009年，正在将Aereus Shield商业化。他们的专利工艺生产出一种耐用的、有吸引力的涂层，事实证明，这种涂层可以在接触时杀灭有害细菌。在加拿大，Aereus Shield是一种专门用于I类和II类医疗设备的抗菌剂。它们的涂层为医院常见病原体提供了一种经济有效的干预措施，是高接触性公共表面的理想解决方案。然而，微生物病原体并不是唯一令人担忧的微生物。病毒可以在表面存活，并可能导致感染在医院等高危环境中传播。通过这笔赠款，更好地了解了两种典型病毒和Aereus公司制备的新型材料涂层之间相互作用的机制。这两种典型病毒，流感和腺病毒，代表了两大类病毒，即包膜和非包膜病毒，并将作为启动Aereus和滑铁卢大学Aucoin实验室之间关系的基础。Aereus和Aucoin将共同解决医院感染问题，首先加深对Aereus材料的理解，然后利用这种理解更好地设计新产品。具体地说，Aucoin将建立一个受控良好的环境舱，在其中可以控制温度和湿度等因素，并将其与Aereus材料的生物杀灭特性隔离开来。这些材料主要以铜为基础，以涂层、粉末和聚合物复合材料的形式出现在金属衬底上。Aucoin团队将在第一部分专注于涂料和粉末，然后将他们的发现扩展到聚合物复合材料的分析。Aucoin在病毒稳定性和量化方面的工作非常适合帮助Aereus将自己定位为独特的杀生材料生产商。鉴于现有的商业协议，Aereus能够利用这些科学发现，其涂层显示出抗微生物特性。