Defining the Role of CARD9 in Monocyte/Macrophage Immunity to Candida albicans

定义 CARD9 在单核细胞/巨噬细胞对白色念珠菌免疫中的作用

• 批准号: 351847
• 负责人: Vinh Donald C
• 金额: $ 7.29万
• 依托单位: Research Institute of the McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-04-01 至 2017-04-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=351847&lang=en
• 关键词: Candida Albicans; Card9; Host Response; Immunity; Macrophages; Monocytes

Invasive fungal infections affect more than 2 million people worldwide annually, and result in death for more than half of these patients. In a healthy immune system, a molecule called CARD9 activates antifungal immune responses and this protects against

侵袭性真菌感染每年影响全球超过200万人，并导致这些患者中一半以上死亡。在健康的免疫系统中，一种名为CARD9的分子激活抗真菌免疫反应，