Structural comparison of human, murine, and rabbit antibodies
Structural comparison of human, murine, and rabbit antibodies
批准号:
499037-2016
负责人:
Evans, Stephen
金额:
$1.82万
依托单位:
依托单位国家:
加拿大
项目类别:
Engage Grants Program
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-01-01 至 2017-12-31
中文摘要
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英文摘要
One of the roadblocks to evaluating the effectiveness of monoclonal antibody (mAb) therapy arises because most mAbs are generated using non-human hosts, which leads to rejection of the therapeutic as 'non-self'. The core service of our industrial collaborator, ImmunoPrecise (IPA), is to use mouse and rabbit systems to generate mAbs with the desired specificities and affinities; however, most non-human antibodies make poor human therapeutics due to a strong immune response against the mouse or rabbit antibody 'framework' and the formation of anti-drug antibodies (ADA).
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批准号:RGPIN-2020-06021
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.23万
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财政年份:2021
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批准号:RGPIN-2019-05287
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.82万
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财政年份:2021
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负责人:Evans, Stephen
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批准号:RGPIN-2020-06021
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.23万
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财政年份:2020
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负责人:Evans, Stephen
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依托单位:
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批准号:RGPIN-2019-05287
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.82万
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财政年份:2020
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负责人:Evans, Stephen
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依托单位:
The field behavior of catastrophic mass flows; hazard assessment and geomorphic impact
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批准号:RGPIN-2019-05287
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.82万
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财政年份:2019
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负责人:Evans, Stephen
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资助金额:$2.19万
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Structural Studies of Protein-Carbohydrate Interactions
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.13万
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负责人:Evans, Stephen
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Rock slopes and rock avalanches in glacial environments of NW North America
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资助金额:$3.13万
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财政年份:2016
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依托单位:
Rock slopes and rock avalanches in glacial environments of NW North America
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批准号:RGPIN-2014-04631
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2016
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负责人:Evans, Stephen
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依托单位:
Structural Studies of Protein-Carbohydrate Interactions
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批准号:171356-2013
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资助金额:$3.13万
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财政年份:2015
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负责人:Evans, Stephen
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依托单位:
Rock slopes and rock avalanches in glacial environments of NW North America
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批准号:RGPIN-2014-04631
-
项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2015
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负责人:Evans, Stephen
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依托单位:
Rock slopes and rock avalanches in glacial environments of NW North America
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批准号:RGPIN-2014-04631
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2014
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负责人:Evans, Stephen
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依托单位:
Structural Studies of Protein-Carbohydrate Interactions
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批准号:171356-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.13万
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依托单位:
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.97万
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财政年份:2013
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负责人:Evans, Stephen
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依托单位:
Structural Studies of Protein-Carbohydrate Interactions
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批准号:171356-2013
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.13万
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财政年份:2013
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负责人:Evans, Stephen
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依托单位:
海外基金