课题基金 / 基金详情

Structural comparison of human, murine, and rabbit antibodies

Structural comparison of human, murine, and rabbit antibodies
人、鼠和兔抗体的结构比较
批准号:
499037-2016
负责人:
Evans, Stephen
金额:
$1.82万
依托单位:
依托单位国家:
加拿大
项目类别:
Engage Grants Program
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-01-01 至 2017-12-31

项目摘要

项目成果

Evans, Stephen的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
One of the roadblocks to evaluating the effectiveness of monoclonal antibody (mAb) therapy arises because most mAbs are generated using non-human hosts, which leads to rejection of the therapeutic as 'non-self'. The core service of our industrial collaborator, ImmunoPrecise (IPA), is to use mouse and rabbit systems to generate mAbs with the desired specificities and affinities; however, most non-human antibodies make poor human therapeutics due to a strong immune response against the mouse or rabbit antibody 'framework' and the formation of anti-drug antibodies (ADA).
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Structural Studies of Protein-Carbohydrate Interactions
  • 批准号:
    RGPIN-2020-06021
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.23万
  • 财政年份:
    2022
  • 负责人:
    Evans, Stephen
  • 依托单位:
The field behavior of catastrophic mass flows; hazard assessment and geomorphic impact
  • 批准号:
    RGPIN-2019-05287
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.82万
  • 财政年份:
    2022
  • 负责人:
    Evans, Stephen
  • 依托单位:
Structural Studies of Protein-Carbohydrate Interactions
  • 批准号:
    RGPIN-2020-06021
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.23万
  • 财政年份:
    2021
  • 负责人:
    Evans, Stephen
  • 依托单位:
The field behavior of catastrophic mass flows; hazard assessment and geomorphic impact
  • 批准号:
    RGPIN-2019-05287
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.82万
  • 财政年份:
    2021
  • 负责人:
    Evans, Stephen
  • 依托单位:
海外基金