Structural comparison of human, murine, and rabbit antibodies

人、鼠和兔抗体的结构比较

• 批准号: 499037-2016
• 负责人: Evans, Stephen
• 金额: $ 1.82万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=607153
• 关键词: Structural; comparison; human; murine; rabbit

One of the roadblocks to evaluating the effectiveness of monoclonal antibody (mAb) therapy arises because most mAbs are generated using non-human hosts, which leads to rejection of the therapeutic as 'non-self'. The core service of our industrial collaborator, ImmunoPrecise (IPA), is to use mouse and rabbit systems to generate mAbs with the desired specificities and affinities; however, most non-human antibodies make poor human therapeutics due to a strong immune response against the mouse or rabbit antibody 'framework' and the formation of anti-drug antibodies (ADA).

评估单克隆抗体（mAb）治疗有效性的障碍之一是因为大多数mAb是使用非人宿主产生的，这导致治疗剂被视为“非自身”而被排斥。我们的工业合作伙伴ImmunoPrecise（IPA）的核心服务是使用小鼠和兔系统生成具有所需特异性和亲和力的mAb;然而，由于对小鼠或兔抗体“框架”的强烈免疫反应和抗药抗体（ADA）的形成，大多数非人抗体对人类的治疗效果较差。