Effect of pubertal probiotic treatment on LPS-induced changes in stress reactivity and anxiety-like behavior in male and female mice.

本研究的目的是研究益生菌对青春期和成年雄性和雌性小鼠暴露于免疫挑战后的应激反应性和焦虑样行为的影响。该项目涉及Lyo-San公司和渥太华大学研究员Nafissa Ismail博士之间的新合作。Lyo-San inc.是一家加拿大家族企业，专门从事乳制品培养物和益生菌的冻干，旨在制作自制酸奶和开菲尔（发酵牛奶），以品牌Yogourmet销售。他们的益生菌培养有利于消化和免疫健康。此次合作的目的是确定在加拿大商业化的开菲尔中添加目前仅在日本销售的乳酸双歧杆菌是否会带来除消化和免疫功能之外的有益效果。更准确地说，合作的目的是研究一种新的益生菌治疗在青春期对心理健康和潜在神经机制的影响。

The objective of this proposal is to study the effects of probiotic administration on stress reactivity and anxiety-like behaviour following exposure to an immune challenge in pubertal and adult male and female mice. This project involves a new collaboration between Lyo-San inc. and Dr. Nafissa Ismail, researcher at the University of Ottawa. Lyo-San inc. is a Canadian family business that specializes in the lyophilization of dairy cultures and probiotics designed to make homemade yogurts and kefir (fermented milk), sold under the brand name Yogourmet. Their probiotic cultures are intended to benefit digestive and immune health. The collaboration will aim to determine if the addition of Bifidobacterium Lactis, currently sold by Lyo-San inc. only in Japan, to their kefir commercialized in Canada, will provide beneficial effects beyond digestion and immune function. More precisely, the objective of the collaboration is to examine the effect of a new probiotic treatment during puberty on mental health and underlying neural mechanisms.