Pubertal, Psychological and Physiological Development in Females with Autism

自闭症女性的青春期、心理和生理发育

• 批准号: 10460717
• 负责人: Blythe Anne Corbett
• 金额: $ 73.43万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10460717
• 关键词: 10 year old; Address; Adolescent; Advanced Development; Age; Age of Onset; Anxiety; Area; Arousal; Behavior; Biological; Body mass index; Breast; Complex; Cross-Sectional Studies; Data; Development; Economics; Education; Electroencephalography; Endocrine; Enrollment; Entire hair of pubis; Environmental Risk Factor; Estradiol; Ethnic Origin; Female; Female Adolescents; Genetic; Goals; Gold; Growth; Height; Hormones; Human; Hydrocortisone; Impairment; Intervention; Link; Luteinizing Hormone; Menstrual cycle; Menstruation; Mental Depression; Mental Health; Neuraxis; Outcome; Peripheral Nervous System; Physiological; Plasma; Population; Psychological Impact; Puberty; Race; Reporting; Research; Risk; Same-sex; Sampling; Series; Services; Social Functioning; Social Interaction; Staging; Stress; Symptoms; Time; Withdrawal; adolescent with autism spectrum disorder; autism spectrum disorder; base; biobehavior; biological adaptation to stress; biopsychosocial; cohort; depressive symptoms; girls; hypothalamic-pituitary-adrenal axis; improved; longitudinal design; male; multimodality; peer; peer victimization; physical conditioning; psychologic; psychosocial; pubertal timing; rate of change; relating to nervous system; research and development; response; service intervention; sex; skills; social; social communication; social skills

Project Summary/Abstract Puberty is among the most complex developmental transitions over the human lifetime. The timing (age of onset) and tempo (rate of change) of puberty can significantly and negatively impact physical, psychosocial and physiological functioning, especially in females. Autism spectrum disorder (ASD) is characterized by impaired reciprocal social communication and poor adaptation to change; thus, the onset and course of puberty marks a pivotal transition. In a series of cross-sectional studies, findings from the study team have shown: 1) advanced pubertal timing for female youth with ASD compared to typically developing females (i.e., breast development, menses) using rigorous assessment of pubertal staging; 2) distinct camouflaging behaviors in females with ASD when socially interacting with peers; 3) higher depressive symptoms in early adolescents with ASD, especially females; 4) sex-based differences in neural socioemotional processing in youth with ASD; and 5) elevated stress and arousal in youth with ASD compared to same-age TD peers that increases with age and pubertal development. Consistent across these studies is the unique profile of females with ASD and the potential deleterious impact of early puberty in this vulnerable, understudied population and developmental window. While the previous and ongoing pubertal development research is compelling, at the start of enrollment, 80% of the 10-year old females with ASD had already entered puberty compared to 29% of the TD group; therefore, the true onset of puberty could not be determined. Moreover, it was based on a relatively small sample of females with ASD 10-13 years (N = 35). Thus, a comprehensive exploration of pubertal maturation in a large sample of younger girls with ASD is needed. The overarching goal is to systematically examine the precise onset, tempo and course of pubertal, psychosocial and physiological development in females with ASD using a multimodal, multimethod, accelerated longitudinal design. A large sample of females with ASD (n=120) and TD (n=120) spanning 6 to 15 years will be followed over four years: Cohort 1 enrolled at 6-years (follow 6-9), Cohort 2 enrolled at 8-years (follow 8-11), Cohort 3 enrolled at 10-years (follow 10-13) and Cohort 4 enrolled at 12-years (follow 12-15). The aims will address three key areas. Aim 1: Pubertal development - will examine the timing, tempo and course of puberty based on physical development (Tanner stage (TS), body mass index (BMI), height, linear growth velocity (LGV)), hormones (Estradiol, Luteinizing Hormone (LH)), and menstrual cycle. Aim 2: Psychosocial profiles - will examine reciprocal social communication (CASS) and internalizing symptoms (anxiety and depression) at the onset and over the course of pubertal development. Aim 3. Physiological characterization - will simultaneously examine social functioning at the level of the central nervous system (EEG hyperscanning), HPA axis (cortisol) and peripheral nervous system (RSA) during naturalistic social interactions between same-sex peers. The findings will reveal the impact of the onset, tempo and course of puberty on females with ASD to improve education, inform services, and develop interventions, which are lacking.

项目摘要/摘要 青春期是人类一生中最复杂的发展过渡之一。时机（发病时代） 和青春期的节奏（变化速度）会对身体，心理社会和 生理功能，尤其是在女性中。自闭症谱系障碍（ASD）的特征是受损 相互的社会交流和对变革的适应不良；因此，青春期的开始和过程标记 关键转变。在一系列横断面研究中，研究小组的发现表明：1）高级 与通常发展女性相比（即乳房发育， 月经）使用严格的青春期分期评估； 2）与ASD的女性中不同的伪装行为 当社交与同龄人互动时； 3）早期ASD青少年的抑郁症状较高，尤其是 女性； 4）ASD年轻人的神经社会情感处理基于性别的差异； 5）应力升高 与ASD年轻人的唤醒相比，与年龄增加的同龄TD同龄人相比 发展。这些研究一致的是ASD的女性的独特特征和潜力 早期青春期对这个脆弱的，研究不足的人口和发展窗口的有害影响。尽管 在入学开始时，以前和正在进行的青春期发展研究令人信服，其中80％ 患有ASD的10岁女性已经进入青春期，而TD组的29％；因此， 无法确定青春期的真实发作。此外，它基于一个相对较小的女性样本 ASD 10 - 13年（n = 35）。因此，在大量样本中对青春期成熟的全面探索 需要ASD的年轻女孩。总体目标是系统地检查精确的发病速度 以及使用多模式的ASD女性的青春期，心理和生理发展的过程 多方法，加速纵向设计。 ASD（n = 120）和TD（n = 120）的大量女性样本 跨越6至15年的时间将在四年中遵循：队列1在6年（随后6-9）中招募，同类群体2 在8年内招收（后面8-11），队列3在10年内入学（随后10 - 13年），同类4招募了12年 （关注12-15）。目的将解决三个关键领域。目标1：青春期发展 - 将检查时机， 基于身体发育（Tanner阶段（TS），体重指数（BMI），身高，身高，高度，速度和青春期疗程 线性生长速度（LGV）），激素（雌二醇，黄体生成激素（LH））和月经周期。目标2： 社会心理特征 - 将检查互惠社会交流（CASS）和内在症状 （焦虑和抑郁）在开始时期和青春期发展过程中。目标3。生理 表征 - 将同时检查中枢神经系统层面的社会功能（EEG 在自然主义社交互动期间 在同性同伴之间。这些发现将揭示发作，节奏和青春期的影响 关于ASD的女性，可以改善教育，为服务提供信息和发展干预措施。