Using discrete gradient surfaces to find surfaces that will differentially bind drug-resistant bacteria

使用离散梯度表面寻找能够差异性结合耐药细菌的表面

• 批准号: 502003-2016
• 负责人: Goh, Cynthia
• 金额: $ 7.18万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=609077
• 关键词: Using; discrete; gradient; surfaces; find

This proposal is about controlling the interaction between surfaces and microbial cells. The goal is to develop an understanding of how different microbes interact with different types of complex surfaces. We hope this knowledge will ultimately allow us to create patterns on a substrate with regions where bacteria of interest bind and other areas where the bacteria does not bind. Having bacteria from a solution bind to a specific defined two-dimensional area on a substrate effectively concentrates initially low numbers of bacteria to allow them to be counted easily under a microscope: It would be like using a magnet to pull a needle from a haystack. This approach will assist in the development of diagnostics for microbes.

这项提议是关于控制表面和微生物细胞之间的相互作用。其目标是了解不同的微生物如何与不同类型的复杂表面相互作用。我们希望这一知识最终将使我们能够在底物上创建图案，其中感兴趣的细菌结合的区域和其他细菌不结合的区域。让细菌从溶液中结合到底物上特定的二维区域，有效地浓缩了最初数量较少的细菌，以便在显微镜下轻松计数：这就像是使用磁铁从干草堆中拔出一根针。这种方法将有助于微生物诊断学的发展。