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Roles of the tumor suppressor PALB2 at the crossroads of DNA double-strand break repair and synthetic lethal strategies

Roles of the tumor suppressor PALB2 at the crossroads of DNA double-strand break repair and synthetic lethal strategies
肿瘤抑制因子 PALB2 在 DNA 双链断裂修复和合成致死策略十字路口的作用
批准号:
355281
负责人:
Masson Jean-Yves
金额:
$70.5万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-10-01 至 2021-10-01

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中文摘要
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英文摘要
Cancer is the leading cause of death in our country. The initial event for cancer formation involves mutations in the genetic material. In recent years, it has been increasing clear that mutations in key DNA repair enzymes such as PALB2 and BRCA2 contribu
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Canada Research Chairs - Tier 1
  • 批准号:
    424788
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2019
  • 负责人:
    Masson Jean-Yves
  • 依托单位:
Patient stratification based on DNA repair functionality for cancer precision medicine
  • 批准号:
    406820
  • 项目类别:
    Operating Grants
  • 资助金额:
    $23.52万
  • 财政年份:
    2019
  • 负责人:
    Masson Jean-Yves
  • 依托单位:
Decoding the DNA double-strand break repair pathways: from mechanistic insights to human genome instability diseases
  • 批准号:
    369216
  • 项目类别:
    Operating Grants
  • 资助金额:
    $245.17万
  • 财政年份:
    2017
  • 负责人:
    Masson Jean-Yves
  • 依托单位:
Mechanisms and regulation of DNA end resection in mammalian cells
  • 批准号:
    343190
  • 项目类别:
    Operating Grants
  • 资助金额:
    $59.59万
  • 财政年份:
    2016
  • 负责人:
    Masson Jean-Yves
  • 依托单位:
海外基金