Roles of the tumor suppressor PALB2 at the crossroads of DNA double-strand break repair and synthetic lethal strategies

肿瘤抑制因子 PALB2 在 DNA 双链断裂修复和合成致死策略十字路口的作用

• 批准号: 355281
• 负责人: Masson Jean-Yves
• 金额: $ 70.5万
• 依托单位: Universit Laval
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=355281&lang=en
• 关键词: Brca1/Brca2/Palb2; Dna Repair; Dna Strand Invasion; Double-Strand Breaks; Genome Stability; Homologous Recombination; Synthetic Lethality

Cancer is the leading cause of death in our country. The initial event for cancer formation involves mutations in the genetic material. In recent years, it has been increasing clear that mutations in key DNA repair enzymes such as PALB2 and BRCA2 contribu

癌症是我国死亡的主要原因。癌症形成的初始事件涉及遗传物质的突变。近年来，越来越清楚的是，关键DNA修复酶如PALB 2和BRCA 2的突变有助于DNA修复。