Control of inflammation by a novel cytosolic Unfolded Protein Response (UPR) pathway

通过新型胞质未折叠蛋白反应 (UPR) 途径控制炎症

• 批准号: 357366
• 负责人: Girardin Stephen E
• 金额: $ 65.76万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=357366&lang=en
• 关键词: Auto-Inflammation; Cellular Stress; Crohn'S Disease; Inflammation; Innate Immunity; Nod-Like Receptors; Pattern Recognition Molecules

Inflammation is controlled by several families of proteins that assemble in large clusters when they are activated. Because this assembly is very much like a "chain reaction" it needs to be controlled at a molecular level, otherwise these clusters would p

炎症是由几个蛋白质家族控制的，当它们被激活时，它们会聚集在一起。因为这种组装非常像“连锁反应”，所以需要在分子水平上进行控制，否则这些团簇就会被破坏。