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Immunotherapy against neuroserpin to correct Nerve Growth Factor metabolic dysfunction and consequent cholinergic and cognitive deficits in a transgenic rat model of Alzheimer's disease.

Immunotherapy against neuroserpin to correct Nerve Growth Factor metabolic dysfunction and consequent cholinergic and cognitive deficits in a transgenic rat model of Alzheimer's disease.
针对神经丝氨酸蛋白酶抑制剂的免疫疗法可纠正阿尔茨海默病转基因大鼠模型中的神经生长因子代谢功能障碍以及随之而来的胆碱能和认知缺陷。
批准号：
365444
负责人：
Pentz Rowan D
金额：
$7.65万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-10-01 至 2019-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=365444&lang=en
关键词：
Alzhiemer'S Disease Basal Forebrain Behavioural Testing Cholinergic System Immunotherapy Inflammation Nerve Growth Factor Neurodegeneration Ngf Metabolic Pathway Transgenic Models

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英文摘要
Alzheimer's disease (AD) is an increasing problem in our aging population. Unless new disease-modifying treatments are discovered, the problem may become unmanageable. In AD, cholinergic neurons of the basal forebrain become atrophic or die, and most brai
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Effects of tissue plasminogen activator administration on cholinergic and cognitive deficits in in a transgenic model of Alzheimer's disease-like amyloid pathology
  • 批准号：
    311872
  • 项目类别：
    Studentship Programs
  • 资助金额：
    $1.27万
  • 财政年份：
    2013
  • 负责人：
    Pentz Rowan D
  • 依托单位：
    McGill University
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