Acombined early and late HIV-1 protein-specific exosome-targeted T cell vaccine capable of stimulating HIV-1 specific CD8+ CTL responses in absence of CD4+ T cells and counteracting immune suppression.
Acombined early and late HIV-1 protein-specific exosome-targeted T cell vaccine capable of stimulating HIV-1 specific CD8+ CTL responses in absence of CD4+ T cells and counteracting immune suppression.
批准号:
182524
负责人:
Xiang Jim
金额:
$6.52万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2009
资助国家:
加拿大
项目状态:
已结题
起止时间:
2009-03-01 至 2010-03-01
中文摘要
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英文摘要
CD4+ T cells are required for generation and maintenance of cytotoxic CD8+ T cells playing a critical role in control of human immunodeficiency virus type-1 (HIV-1) proliferation. However, CD4+ T cell depletion usually occurs in acquired immunodeficiency
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会议论文
Distinct regulation of T cell fate and memory via differentially IL-2- and IL-7-activated mTORC1-KIF13A-M6PR axis and AMPK-FOXO-Eomes pathway
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批准号:354414
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项目类别:Operating Grants
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资助金额:$34.27万
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财政年份:2016
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负责人:Xiang Jim
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依托单位:
Combined late and early HIV-1 protein-specific exosome-targeted T cell-based vaccine capable of stimulating CTL responses in absence of CD4+ T cell help
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批准号:275588
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项目类别:Operating Grants
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资助金额:$21.48万
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财政年份:2012
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负责人:Xiang Jim
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依托单位:
A combined early and late HIV-1 protein-specific exosome-targeted T cell vaccine capable of counteracting immune supression and stimulating CD8+ CTL responses in absence of CD4+ T cells. A future therapeutic HIV-1 vaccine.
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批准号:177551
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项目类别:Operating Grants
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资助金额:$9.06万
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财政年份:2008
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负责人:Xiang Jim
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依托单位:
海外基金