Linking Inactivating Mutations in Chromatin Remodeling Complex Subunits to Aggressive Dedifferentiated Endometrial Carcinoma

染色质重塑复合体亚基失活突变与侵袭性去分化子宫内膜癌的联系

• 批准号: 365454
• 负责人: Coatham Mackenzie L
• 金额: $ 7.65万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2019-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=365454&lang=en
• 关键词: Arid1b; Brg1; Cellular Dedifferentiation; Dedifferentiated Endometrial Carcinoma; Epigenetics; Next Generation Sequencing; Patient Derived Xenograft Models; Stem-Cell Phenotype; Swi/Snf Chromatin Remodelling Complex; Targeted Therapy

Most recently, cancers of the ovaries, endometrium and even lungs have been hypothesized to originate from the unchecked growth of dedifferentiated cells that most closely resemble embryonic stem cells. Specialized cells constituting these organs revert b

最近，人们假设卵巢癌、子宫内膜癌甚至肺癌起源于与胚胎干细胞最相似的去分化细胞的不受控制的生长。构成这些器官的特殊细胞恢复b