Developing a new class of RNA delivery vehicle using synthetic virology

利用合成病毒学开发新型 RNA 递送载体

• 批准号: FT230100084
• 负责人: Dr Frank Sainsbury
• 金额: $ 66.76万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100084
• 关键词: Developing; new; class; RNA; delivery

This project aims to develop robust protein cages derived from the empty shells of viruses, or capsids, to protect and deliver sensitive cargo such as RNA in agricultural settings. It will do so by directed evolution of non-infectious capsids in the lab. This will uncover the molecular mechanisms underpinning the response of viruses to chemical and biological signals and create a new class of RNA delivery vehicle. This synthetic biology approach combines virology and protein engineering to establish a platform biotechnology for stable and effective delivery. The project expects to demonstrate the potential of nature’s nanoparticles, virus capsids, to enhance the efficacy of RNA technologies in a wide range of applications.

该项目旨在开发来自病毒或衣壳的空壳的强大蛋白质笼，以保护和运送农业环境中的敏感货物，如RNA。它将通过在实验室中定向进化非传染性衣壳来实现。这将揭示病毒对化学和生物信号反应的分子机制，并创造出一类新的RNA运载工具。这种合成生物学方法结合了病毒学和蛋白质工程，建立了一个稳定有效的生物技术平台。该项目预计将展示自然界的纳米颗粒，病毒衣壳，以提高RNA技术在广泛应用中的功效的潜力。